Method for supercritical CO2 extraction of entada phaseoloides

A supercritical, vine seed technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc. problems such as low concentration, to achieve the effect of improving extraction performance, high extraction rate and low extraction temperature

Inactive Publication Date: 2022-02-11
湖南汉华京电清洁能源科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are literature reports on the extraction process of the fruit of the vine extract, which are mainly water extraction, ethanol extraction and other processes, but the purity of the obtained product is not high, the steps are numerous and lengthy, and light and oxidative decomposition are very prone to occur in the production process, and the concentration of the extract is low. , did not effectively utilize the active ingredients in the vine fruit

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 100g of the peeled vine fruit, grind the particle size to about 0.1mm-1.5mm, put it into the extraction kettle after drying, and use supercritical CO 2 As a solvent, 75% ethanol is used as an entrainer. The extraction conditions are: the extraction pressure is 24MPa, and the temperature is 50°C; the separation conditions are: the pressure of the primary separator is 8MPa, the temperature is 50°C, and the pressure of the secondary separator is 5MPa , the temperature is 40 ℃; after dynamic operation for 4 hours, the extract of the fruit of fructus vine obtained from the primary separator and the secondary separator is 675ml, and the productive rate reaches 94%.

Embodiment 2

[0025] The difference between this example and Example 1 is that the extraction pressure is 26MPa, the temperature is 60°C, the primary separator pressure is 10MPa, the temperature is 60°C, the secondary separator pressure is 6MPa, the temperature is 40°C, 85% ethanol As an entrainer, after 3 hours of dynamic operation, the extract of the fruit of the fructus vine obtained from the primary separator and the secondary separator is 710ml, and the productive rate is 92.7%.

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PUM

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Abstract

The invention discloses a method for supercritical CO2 extraction of entada phaseoloides. The method comprises the following steps: drying peeled entada phaseoloides powder at 65 DEG C or below for 6-12 hours; performing supercritical CO2 extraction; and carrying out two-stage decompression separation on the obtained extract to respectively obtain entada phaseoloides extracting solutions. Compared with the prior art, the extraction temperature is low, the extraction speed is high, the extraction rate is high, and the original properties of substances are effectively reserved; the method has the advantages of no organic solvent residue, high selectivity, high yield, low toxicity and the like, and has no adverse effect on human and environment; and the problem of oxidative degradation in the production process is effectively prevented.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical processing, in particular to an efficient and environment-friendly extraction method for active ingredients of Fructus vine, specifically a supercritical CO 2 The method of extracting vine fruit. Background technique [0002] Tengzi is the dried seed kernel of Tengzi, a plant of the genus Tengzi in the family Fabaceae, and is a traditional medicinal material in the Dai area. There are 58 species of vines in the world, mainly distributed in tropical and subtropical regions. There is only one species of Entadaphaseoloides (Linn.) Merr. in mainland my country. It is mainly used to treat hemorrhoids, stomach pain, constipation, edema and other diseases. Modern pharmacological studies have shown that the plants of the genus Ficus have various biological activities such as antibacterial, antioxidant, antitumor, anti-inflammatory and analgesic. Cone contains fatty oils, including triglycerides...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61K131/00
CPCA61K36/48A61K2236/37A61K2236/17
Inventor 熊书浩金家琪蒋攀峰何聪刘磊
Owner 湖南汉华京电清洁能源科技有限公司
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