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Bovine bone peptide composition and application thereof in preparation of medicine for regulating intestinal flora and preventing and treating osteoporosis

The technology of a peptide composition and bovine bone peptide is applied to the application field of bovine bone peptide composition, preparation of drugs for regulating intestinal flora and preventing and treating osteoporosis, which can solve the problems of insignificant effect and the like, and achieves improvement of intestinal metabolism. Function and effects of gut health, weight improvement, abundance reduction

Pending Publication Date: 2022-02-15
ANHUI GUOTAI BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although bovine ossotide is an important source of drugs for the prevention and treatment of osteoporosis, the clinical effect of bovine ossotide alone is not significant
So far, there is no public report on Eucommia ulmoides and Achyranthes bidentata combined with bovine bone peptide for remodeling intestinal flora to prevent and treat osteoporosis

Method used

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  • Bovine bone peptide composition and application thereof in preparation of medicine for regulating intestinal flora and preventing and treating osteoporosis
  • Bovine bone peptide composition and application thereof in preparation of medicine for regulating intestinal flora and preventing and treating osteoporosis
  • Bovine bone peptide composition and application thereof in preparation of medicine for regulating intestinal flora and preventing and treating osteoporosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The bovine bone peptide composition prepared by embodiment 1 bovine bone peptide, Eucommia ulmoides and Achyranthes bidentata

[0026] This example provides a bovine bone peptide composition prepared from bovine bone peptide, Eucommia ulmoides and Achyranthes bidentata. Specific steps are as follows:

[0027] Mix 30g of eucommia ulmoides and 15g of Achyranthes bidentata with 500mL of water, heat and boil for 1 hour, add 10g of yak bone peptide or yellow bovine bone peptide, continue to boil for 15 minutes, filter, and remove the medicine residue.

Embodiment 2

[0028] The oral liquid prepared by embodiment 2 bovine bone peptide, Eucommia ulmoides and Achyranthes bidentata

[0029] This example provides oral liquid prepared from bovine bone peptide, Eucommia ulmoides and Achyranthes bidentata. Specific steps are as follows:

[0030] Take 50g Eucommia ulmoides and 50g Achyranthes bidentata decoction pieces and add 600mL of water to immerse, soak the medicinal materials for 1h, boil and continue heating for 1h, heat and boil to 120mL, remove the medicinal residues, leave the decoction at room temperature, add 20g of bovine bone peptide to fully dissolve , adding appropriate pharmaceutically acceptable auxiliary materials to make oral liquid.

Embodiment 3

[0031] Example 3 Eucommia ulmoides extract, Achyranthes bidentata extract and bovine osseopeptide preparation of bovine osseopeptide composition

[0032] This example provides a bovine bone peptide composition prepared from the extract of Eucommia ulmoides, the extract of Achyranthes bidentata and bovine bone peptide. Specific steps are as follows:

[0033] Mix 48g of Eucommia Eucommia and 24g of Achyranthes bidentata with 800mL of water, heat and boil to 300mL, remove the dregs, and freeze-dry to obtain Eucommia extract powder and Achyranthes bidentata extract powder respectively. 1. Mix the yak bone peptide evenly according to the weight ratio of 10:5:30.

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Abstract

The invention relates to the technical field of bioactive peptides, in particular to a bovine bone peptide composition and application thereof in preparation of drugs for regulating intestinal flora and preventing and treating osteoporosis, and the bovine bone peptide composition provided by the invention comprises bovine bone peptide, eucommia ulmoides and achyranthes bidentata. The bovine bone peptide composition provided by the invention can be used for preventing and treating osteoporosis, promoting growth and development of thighbone, regulating calcium and phosphorus metabolism, promoting bone formation and reducing bone resorption. Through animal in-vivo biological evaluation, the bovine bone peptide composition provided by the invention can change the intestinal flora diversity and species community composition of mice, so that the disordered intestinal flora tends to be normal, and bone metabolism is regulated, thereby improving osteoporosis.

Description

technical field [0001] The invention relates to the technical field of bioactive peptides, in particular to a bovine bone peptide composition and its application in the preparation of drugs for regulating intestinal flora and preventing and treating osteoporosis. Background technique [0002] In addition to its own cells, there are hundreds of trillions of microorganisms in the human body, about 90% of which exist in the human intestinal tract, known as the intestinal flora. With the continuous development of technology, researchers have found that the intestinal flora is not only related to human personality, aging and other physiological states, but also closely related to the occurrence and development of various human diseases, such as inflammatory bowel disease, asthma and other autoimmune diseases. disease, osteoporosis, even brain disorders like Parkinson's, and more. Some researchers have also suggested that regulating intestinal flora may be an effective way to tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A23L33/18A23L33/105A61P19/10A61P1/00
CPCA61K38/012A61K36/46A61K36/21A61P19/10A61P1/00A23L33/18A23L33/105A61K2236/331A61K2236/39A61K2236/53A61K2236/51A23V2002/00A61K2300/00A23V2200/306A23V2200/32A23V2250/21A23V2250/55
Inventor 衣大龙任雪玲郭汝悦段毅超臧春华刘怀高张恒
Owner ANHUI GUOTAI BIOTECHNOLOGY CO LTD
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