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Pharmaceutical composition for corneal tissue repair of insulin nano system and application of pharmaceutical composition

A technology of tissue repair and insulin, applied in the direction of nano-medicine, drug combination, nano-technology, etc., can solve problems such as poor effect, and achieve improvement of patient compliance, anti-apoptotic corneal cell and nerve repair, and low frequency of administration Effect

Pending Publication Date: 2022-03-01
THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the other hand, for some refractory corneal ulcers, traditional methods of anti-inflammation, anti-infection, promotion of corneal repair and amniotic membrane transplantation are not effective.

Method used

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  • Pharmaceutical composition for corneal tissue repair of insulin nano system and application of pharmaceutical composition
  • Pharmaceutical composition for corneal tissue repair of insulin nano system and application of pharmaceutical composition
  • Pharmaceutical composition for corneal tissue repair of insulin nano system and application of pharmaceutical composition

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Embodiment

[0025] Example: The pharmaceutical composition of insulin nanosystems for corneal tissue repair, including liposomes and insulin wrapped in liposomes, the pharmaceutical composition of insulin nanosystems for corneal tissue repair can be applied to corneal repair, its preparation steps as follows:

[0026] S1. Uniformly dissolve soybean lecithin, distearoylphosphatidylethanolamine-polyethylene glycol 2000 (DSPE–PEG2000) and cholesterol in chloroform to obtain solution 1, and put solution 1 into a flask and pass through a water bath Rotary evaporation forms a uniform liposome film.

[0027] S2. Add 2 ml of phosphate-buffered saline (PBS) to the flask in step S1, fully hydrate and elute to obtain a thin film eluent.

[0028] S3. Weigh 5 mg of insulin, and dissolve the insulin in 100 μL of dilute hydrochloric acid with a pH of 2, and then add 1 mL of phosphate buffered saline (PBS) and 100 μL of perfluorooctyl bromide (PFOB) to obtain a solution 2. Make solution 2 ultrasonicall...

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Abstract

The invention discloses a pharmaceutical composition for corneal tissue repair by an insulin nano system and application of the pharmaceutical composition, and belongs to the technical field of pharmaceutical compositions, and the pharmaceutical composition is characterized by comprising nano materials such as lipidosome and insulin wrapped in the nano materials such as lipidosome; the pharmaceutical composition for corneal tissue repair by the insulin nano system is applied to corneal repair. The invention is mainly used for providing a novel preparation ophthalmic pharmaceutical composition which has the advantages of safety, effectiveness, side effect and low administration frequency, and can effectively improve the compliance of patients; meanwhile, the ophthalmic pharmaceutical composition has important biological effects of resisting inflammation, resisting apoptosis and promoting corneal cell and nerve repair, and has more advantages in the treatment effects of resisting inflammation, resisting infection, promoting corneal repair and strengthening amniotic transplantation compared with a traditional treatment method.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical compositions, in particular to pharmaceutical compositions and applications of insulin nanosystems for corneal tissue repair. Background technique [0002] Corneal injuries caused by various reasons, such as severe dry eye, infectious or non-infectious keratitis, chemical burns, corneal transplant rejection, poor repair after various corneal operations, and corneal trauma are still the main and common clinical problems. For corneal diseases, despite corresponding treatment, the effect of some patients is still unsatisfactory, forming refractory corneal diseases. In this case, the infiltration of some cytokines and inflammatory factors in tear fluid and corneal tissue may lead to delayed corneal epithelial healing, recurrent corneal ulcers, new blood vessels, edema, corneal opacity, and decreased vision. Therefore, it is particularly important for the treatment of similar corneal diseases. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/28A61K9/127A61P27/02A61P29/00B82Y5/00
CPCA61K38/28A61K9/127A61K9/0048B82Y5/00A61P27/02A61P29/00A61K9/1271
Inventor 杜之渝
Owner THE SECOND AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV
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