Traditional Chinese medicine formula for promoting calcium supplement of perimenopausal women

Abstract

Aiming at perimenopausal osteoporosis, key gene targets of perimenopausal female osteoporosis are mined by combining medication experience of a national doctor with a life big data technology, and key compounds for regulating and controlling the key gene targets are found through a network pharmacological system tool; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 5 to 40 parts of rhizoma polygonati, 5 to 30 parts of radix puerariae, 5 to 30 parts of flos sophorae, 5 to 20 parts of maca, 2 to 30 parts of fructus lycii, 2 to 30 parts of radix polygonati officinalis, 2 to 20 parts of poria cocos, 2 to 20 parts of folium llicis latifoliae and 2 to 30 parts of chlorella. The traditional Chinese medicine composition is used for performing multi-dimensional system regulation and control on osteoporosis caused by special physiology of females in the perimenopausal period, effectively promotes calcium absorption, and can also be matched with a calcium preparation for use.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine prescription for promoting calcium supplementation of perimenopausal women. Background technique [0002] Perimenopause refers to a period of women before and after menopause, which is a period of normal physiological changes, mainly caused by the decline of ovarian function, and the endocrine, biological and clinical characteristics related to menopause appear, generally starting from about 45 years old to 1 year after menopause . Osteoporosis (OP) in perimenopausal women is mainly related to the decline of ovarian function and the decline of estrogen levels in women during this period. A skeletal disorder characterized by consequent increased bone fragility and increased fracture risk. [0003] Hormone replacement therapy (HRT) is currently the first-line therapy for the prevention and treatment of perimenopausal osteoporosis, but an...

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Problems solved by technology

These calcium supplement formulas and products are only designed from the perspective of calcium absorption. These patents do not provide calcium supplement for the physiological characteristics of perimenopausal women, and cannot fundamentally solve the problem of osteoporosis in perimenopausal women

[0006] Chinese patent CN201410634969.4 discloses a traditional Chinese medicine composition for treating perimenopausal syndrome. Composition of Salvia miltiorrhiza and Uncaria; Chinese patent CN201610839832.1 discloses antler powder for treating perimenopausal syndrome, the formula is made of antler, fried yam, and donkey-hide gelatin; The ointment for conditioning period syndrome and its preparation method, the formula is donkey-hide gelatin, tortoise shell glue, yam, medlar, mulberry, kudzu root, sealwort, cinnamon, poria cocos, jujube seed, anemarrhena, licorice, walnut kernel, black sesame, rock sugar, rice wine ; but perimenopausal osteoporosis is only one of the typical symptoms, prevention and treatment of perimenopausal osteoporosis cannot be equal to the prevention and treatment of perimenopausal syndrome, and the above prescriptions have not been screened from the molecular mechanism of perimenopausal osteoporosis The most suitable drug prescription lacks science and effectiveness

[0007] In addition, the national food safety standard "Standards for the Use of Food Nutritional Fortifiers" (GB 14880—2012) stipulates that the amount of calcium added to beverages is 160 mg / kg - 1350 mg / kg. At present, the daily consumption of liquid foods related to calcium preparations in China About 100mL, the maximum amount of calcium added according to laws and regulations is only 135 mg, even if 500mg of calcium can be obtained from food every day, the total amount is far from reaching the daily calcium intake of perimenopausal women The requirement of 1000-1500mg / day has little anti-osteoporosis effect on perimenopausal women, and this problem also exists in other kinds of foods

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