Skin protection composition comprising kaempferol glycoside compound

A technology of kaempferol glycoside and kaempferol glycoside, which is applied in the field of skin protection compositions, can solve problems such as skin side effects and ineffective effects, and achieve improvement of skin wrinkles, improvement of atopic skin, prevention or treatment of atopy The effect of dermatitis

Pending Publication Date: 2022-03-15
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, most of the existing cosmetic raw materials have various p

Method used

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  • Skin protection composition comprising kaempferol glycoside compound
  • Skin protection composition comprising kaempferol glycoside compound
  • Skin protection composition comprising kaempferol glycoside compound

Examples

Experimental program
Comparison scheme
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Example Embodiment

[0160] Example

[0161] The cameras used in the experiment was obtained by the crest method of producing oil by crushing by crushing. The extract was prepared from the mateted oil from the cameras using 70% ethanol and confirmed that the machae seed oil extract was composed of terpene glycoside, flavonoids, sugar and protein. In particular, the flavonoids of the cameras of the cameotese of the malaushenol (chemicals 1, 2, 3, 4) and tritamin (chemical formula 5, 6, 7, 8) are confirmed in the spectrum seed in this specification. 4 tetraquinol (chemicals 1, 2, 3, 4) in oil pearlisin glycosides have excellent skin anti-aging and regenerative effects.

[0162] 1) Purification of hillophenol sugar distillate in matrix seed oil

[0163] 8 kg of 70% ethanol was added to 1 kg of tea seed oil, which was removed from the low-warmest oil, and the heating extractor was extracted at 60 ° C for 8 hours. The extract obtained by filtration of the filtered filter was concentrated under reduced pres...

Example

[0170] Experimental Example 1: Confirmation of SA-β-GAL expression degree of aging markers

[0171] The DMEM medium having an experimental substance (2 μM or 3 μm) was replaced and cultured for 48 hours. The supernatant is then collected and the amount of MMP-1 is determined using the total MMP-1ELISA (R & D Systems). The result is as image 3 Indicated.

[0172] Refer image 3 It can be confirmed that the matrix phenol tetragonin compound (chemical formula 1, chemical formula 3, and chemical formula 4) of the present invention is compared to control group such as hillol tritamoside compound (chemical formula 5 and chemical formula 7) and retinoic acid (RA). The suppression of MMP-1 expression is more excellent.

Example

[0173] Experimental Example 4: Confirmation of Skin Barrier Improvement

[0174] 1) 3D organ type skin epidermis

[0175] Purchase corresponding to young people (21 years old, representing 21Y) and the elderly (58 years old, expressed as 58Y) TM Epi-201; Mattek, USA Massachusetts Ashlo, with 3 μm of the hull phenol tetra glycoside represented by the chemical formula 1 in the human skin model corresponding to the elderly. 4 days. After 10% neutral buffer formalin, stone wax block was prepared.

[0176] 2) Confirmation of skin barrier markers

[0177] Using anti-KRT10 (Biolegend, US California San Diego), anti-FLG (Novus Biologics, US Colorado Sutiel), anti-proximal protein and anti-Ki67 (ABCAM company) antibody, analyzed each antibody under microscope expression. Specifically, epidermis tissue from the young donor (young 21Y) and epidermal tissue from the elderly donor (Elderly 58Y) were carried out, and then stained with the above antibody and quantified. The result is as Figure 4...

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Abstract

The present specification provides a composition for skin protection, which contains, as an active ingredient, a kaempferol glycoside compound that is extracted from Camellia seed oil meal discarded after extraction of oil from Camellia seeds, and thus is environmentally friendly, safe to the human body due to few side effects, and excellent in effects such as skin regeneration.

Description

Technical field [0001] The present invention discloses a skin protective composition comprising a hull phenol glycoside compound having a safe and excellent skin protection effect of the human body. Background technique [0002] The skin is the first defense barrier in the human body, and the organs in the protective body are excited by temperature and humidity, ultraviolet and pollutants, etc., and the maintenance of body temperature is also played an important role in maintaining body temperature adjustment. [0003] However, due to excessive physical and chemical stimulation and pressure, nutrition lack such as age growth, the normal function of the skin decreases, and will promote resilient loss, hornification, wrinkle generation and other phenomena. In order to prevent this phenomenon and maintain a more healthy and elastic skin, it has been committed to maintaining the solid function of the skin by using a physiologically active substance to maintain the skin's inherent fun...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K8/60A61Q19/00A61P17/00A61P37/08A61K36/82
CPCA61K31/7048A61K8/602A61Q19/00A61P17/00A61K2800/782A61K36/82A61Q19/08A61P17/18A23L33/105A23V2002/00A23V2200/318A23V2250/2116A61K9/0014A61K8/9789A61K2800/92
Inventor 高在濚曹始永金泂洙赵成衍金亨俊白兴洙孙义东
Owner AMOREPACIFIC CORP
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