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Magnesium-based multifunctional composite active coating as well as preparation method and application thereof

An active coating and functional technology, applied in the field of magnesium-based multifunctional composite active coating and its preparation, can solve the problems of implants losing mechanical integrity, poor biocompatibility, and rapid corrosion, and achieve good cell compatibility Good adhesion, good adhesion, corrosion inhibitory effect

Pending Publication Date: 2022-03-18
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to solve the technical problems of too fast and uncontrollable corrosion of existing magnesium-based implants in clinical applications, rapid corrosion causes implants to lose mechanical integrity prematurely, and poor biocompatibility

Method used

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  • Magnesium-based multifunctional composite active coating as well as preparation method and application thereof
  • Magnesium-based multifunctional composite active coating as well as preparation method and application thereof
  • Magnesium-based multifunctional composite active coating as well as preparation method and application thereof

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preparation example Construction

[0046] A kind of preparation method of magnesium-based multifunctional composite active coating of the present invention comprises the following steps:

[0047] (1) Prepare ammonium trifluorotitanate active coating on magnesium-based surface by hydrothermal reaction method;

[0048] (2) Using a hydrothermal reaction method to modify the ammonium trifluorotitanate active coating with functional organic molecules;

[0049] (3) Constructing a metal-organic framework active coating on the surface of functional organic molecules by a solvothermal method, and the functional organic molecule layer is used to improve the heterogeneous nucleation of metal-organic framework grains on the surface of the ammonium trifluorotitanate layer .

[0050] In some embodiments, step (1) adopts hydrothermal reaction method to prepare NTiF coating on magnesium-based surface:

[0051] First, use 400#, 1000#, 2000# sandpaper to The surface was polished and ultrasonically cleaned in ethanol and acet...

Embodiment 1

[0067] Step 1, adopting hydrothermal reaction method to prepare NTiF coating on magnesium-based surface;

[0068] First, use 400#, 1000#, 2000# sandpaper to The surface was polished and ultrasonically cleaned in ethanol and acetone in turn, and dried for use. Configure 0.3mol / L NH 4 F aqueous solution, take the prepared 250μL NH 4 F solution and 300μL 40% HF solution were added to 15mL absolute ethanol, mixed completely under magnetic stirring for 10min, then added 500μL tetraisopropyl titanate (TBOT), and magnetically stirred again for 15min, after TBOT was fully hydrolyzed, together with The surface-treated magnesium-based material was placed in a 50mL polytetrafluoroethylene reactor liner for hydrothermal reaction. The hydrothermal temperature was 160°C and the hydrothermal time was 8h. After cooling to room temperature, the samples were taken out and rinsed with ethanol and acetone respectively. Dry for later use to obtain NTiF coating, such as figure 1 shown.

[006...

Embodiment 2

[0074] Step 1, adopting hydrothermal reaction method to prepare NTiF coating on magnesium-based surface;

[0075] First, use 400#, 1000#, 2000# sandpaper to The surface was polished and ultrasonically cleaned in ethanol and acetone in turn, and dried for use. Configure 0.3mol / L NH 4 F aqueous solution, take the prepared 250μL NH 4 F solution and 300μL 40% HF solution were added to 15mL absolute ethanol, mixed completely under magnetic stirring for 10min, then added 500μL tetraisopropyl titanate (TBOT), and magnetically stirred again for 15min, after TBOT was fully hydrolyzed, together with The surface-treated magnesium-based material was placed in a 50mL polytetrafluoroethylene reactor liner for hydrothermal reaction. The hydrothermal temperature was 140°C and the hydrothermal time was 6h. After cooling to room temperature, the samples were taken out and rinsed with ethanol and acetone respectively. Dry for later use to obtain NTiF coating, such as figure 2 shown.

[00...

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Abstract

The invention relates to a magnesium-based multifunctional composite active coating as well as a preparation method and application thereof, and belongs to the technical field of biomedical material preparation. Comprising a magnesium-based matrix as well as an ammonium trifluorotitanate active coating and a metal organic framework active coating which are sequentially arranged outwards from the surface of the magnesium-based matrix, a functional organic molecular layer is also arranged between the ammonium trifluorotitanate active coating and the metal organic framework active coating. The preparation method comprises the following steps: preparing the NTiF coating on the magnesium-based surface by adopting a hydrothermal reaction method, and modifying the surface of the NTiF coating through functional organic molecules by adopting the hydrothermal reaction method; and finally, constructing the metal organic framework active coating on the surface of the coating by adopting a solvothermal method. The obtained multifunctional composite coating is complete in structure, basic functions of controllable corrosion, mechanical integrity and surface biocompatibility of the medical magnesium-based material implant and multifunctional platform construction of drug guest molecule loading and releasing are achieved, and various complex clinical requirements of diagnosis, treatment, antibiosis, anti-inflammation and the like are met.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, and more specifically relates to a magnesium-based multifunctional composite active coating, a preparation method and an application. Background technique [0002] Magnesium and its alloys have unique degradable properties, and the main degradation product is Mg 2+ It is one of the essential ions in the human body. As a matrix material for bone replacement hard tissue implants and degradable cardiovascular stents, it can avoid the damage and cost caused by secondary operations, and has received extensive attention and research. However, the main factor restricting the large-scale clinical application of magnesium-based implants is that the corrosion of magnesium is too fast and uncontrollable. The rapid corrosion causes the implant to lose its mechanical integrity prematurely, hydrogen gas accumulates at the implant site, and body fluids are alkalized, which hinders th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/28A61L27/04A61L27/50A61L27/54A61L27/58
CPCA61L27/306A61L27/28A61L27/047A61L27/50A61L27/54A61L27/58A61L2300/606A61L2420/02A61L2420/08A61L2300/41A61L2300/602A61L2300/404
Inventor 齐锴刘晓邦邱于兵郭兴蓬
Owner HUAZHONG UNIV OF SCI & TECH
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