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Application of lily antiphlogistic pill as or in preparation of medicine for preventing and treating cisplatin acute kidney injury

An acute kidney injury and drug technology, applied in the application field of Baihe Gujin Pill as or preparing a drug for preventing and treating cisplatin acute kidney injury, to achieve the effects of alleviating acute kidney injury, improving acute kidney injury, and improving cell damage

Pending Publication Date: 2022-04-05
TIANJIN UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no published literature reporting that Baihe Gujin Pills can be used to prevent and treat cisplatin-induced acute kidney injury.

Method used

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  • Application of lily antiphlogistic pill as or in preparation of medicine for preventing and treating cisplatin acute kidney injury
  • Application of lily antiphlogistic pill as or in preparation of medicine for preventing and treating cisplatin acute kidney injury
  • Application of lily antiphlogistic pill as or in preparation of medicine for preventing and treating cisplatin acute kidney injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0058] 1 MTT detection of the effect of Baihe Gujin pills on cell viability

[0059] 1.1 Experimental method

[0060] HK-2 cells and HEK-293 cells were placed in DMEM / F12 and DMEM low-glucose cell culture medium containing 1% penicillin-streptomycin solution (double antibody) and 10% fetal bovine serum, respectively, at 37°C for 5 %CO 2 Incubator cultivation. After the cells were digested with trypsin, counted with a hemocytometer, the cell density was adjusted to 5×10 4 cells / mL, inoculated on a 96-well plate, and added 100 μL of cell suspension to each well. At 37°C, 5% CO 2 Cultivate in the culture medium for 24 hours, add Lily Gujin pill liquid with different concentration gradients, 0.5 μL per well, set up 3 duplicate wells for each drug concentration, set up blank wells and control wells at the same time, at 37°C, 5% CO 2 After culturing in the culture medium for 48 hours, 20 μL of 5 mg / mL MTT solution (prepared in PBS, sterilized by filtration with a 0.22 μm filter...

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Abstract

The invention discloses an application of a lily antiphlogistic pill in serving as or preparing a medicine for preventing and treating cisplatin acute kidney injury. The invention discusses the application of the traditional Chinese medicine Lily Gangjin Wan for relieving the cisplatin-induced acute kidney injury by using the Lily Gangjin Wan on a cisplatin-induced acute kidney injury in vitro cell model, wherein the Lily Gangjin Wan can nourish yin and moisten lung, and prevent phlegm from forming and stop coughing. Results show that the cis-platinum-induced acute kidney injury can be remarkably improved by using the lilium antiphlogistic pill on an in-vitro model for intervention treatment. According to the invention, a new application is developed for the utilization of the lily antiphlogistic pill, the treatment range of the lily antiphlogistic pill is expanded, and meanwhile, a new traditional Chinese medicine treatment method is developed for the disease of cisplatin acute kidney injury.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to the application of Baihe Gujin Pills as or in the preparation of medicines for preventing and treating acute kidney injury caused by cisplatin. Background technique [0002] Cisplatin (CDDP) is a clinical first-line antineoplastic drug, mainly used in the treatment of head and neck cancer, lung cancer, ovarian cancer and other solid malignant tumors. Cisplatin can prevent DNA replication, affect RNA and protein synthesis, and lead to tumor cell apoptosis. However, as a non-specific antitumor drug, cisplatin may cause various adverse reactions during chemotherapy, including nephrotoxicity, ototoxicity, peripheral neuropathy, and allergic reactions, among which nephrotoxicity is the most common. The dose-dependent nephrotoxicity of cisplatin greatly limits its clinical application. The molecular mechanism of cisplatin-induced acute kidney injury is complex. Current research mai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P13/12
Inventor 滕玉鸥荣耀姚佳萍徐烨黄梓豪车林择高嘉霖万婷婷向岑刘振郁彭
Owner TIANJIN UNIV OF SCI & TECH
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