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Application of Zhibai Dihuang pill as or in preparation of medicine for preventing and treating cisplatin acute kidney injury

A technology of Zhibai Dihuang Pills and acute kidney injury, applied in the application field of Zhibai Dihuang Pills in the prevention and treatment of cisplatin acute kidney injury drugs, to achieve the prevention and treatment of cisplatin acute kidney injury, reduce acute kidney injury, and improve cell damage Effect

Pending Publication Date: 2022-04-12
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Through searching, there is no published literature reporting that Zhibai Dihuang Pills are used to prevent and treat cisplatin-induced acute kidney injury

Method used

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  • Application of Zhibai Dihuang pill as or in preparation of medicine for preventing and treating cisplatin acute kidney injury
  • Application of Zhibai Dihuang pill as or in preparation of medicine for preventing and treating cisplatin acute kidney injury
  • Application of Zhibai Dihuang pill as or in preparation of medicine for preventing and treating cisplatin acute kidney injury

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Experimental program
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Embodiment

[0062] 1MTT detection of the effect of Zhibai Dihuang Pills on cell viability

[0063] 1.1 Experimental method

[0064] HK-2 cells and 293T cells were placed in DMEM / F12 and DMEM low-glucose cell culture medium containing 1% penicillin-streptomycin solution (double antibody), 10% fetal bovine serum, respectively, at 37°C and 5% CO 2 Incubator cultivation. After the cells were digested with trypsin, counted with a hemocytometer, the cell density was adjusted to 5×10 4 cells / mL, inoculated on a 96-well plate, and added 100 μL of cell suspension to each well. At 37°C, 5% CO 2 Cultivate in the culture medium for 24 hours, add Zhibai Dihuang pill liquid with different concentration gradients, 0.5 μL per well, set 3 duplicate wells for each drug concentration, and set blank wells and control wells at the same time, at 37 ° C, 5% CO 2 After culturing in the culture medium for 48 hours, 20 μL of 5 mg / mL MTT solution (prepared in PBS, sterilized by filtration with a 0.22 μm filter...

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Abstract

The invention discloses an application of Zhibai Dihuang pills as or in preparation of a medicine for preventing and treating cisplatin acute kidney injury. The Zhibai Dihuang pill is used on a cis-platinum-induced acute kidney injury in-vitro cell model and an in-vivo animal model, and the application of the Yin-nourishing and fire-reducing Chinese patent medicine Zhibai Dihuang pill in relieving the cis-platinum-induced acute kidney injury is discussed. The result shows that the acute kidney injury induced by cis-platinum can be obviously improved by using the Zhibai rehmannia pill for intervention treatment on an in-vivo and in-vitro model. The invention develops a new application for the utilization of the Zhibai Dihuang pill, widens the treatment range of the Zhibai Dihuang pill, and opens up a new traditional Chinese medicine treatment method for the cisplatin acute kidney injury.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to the application of Zhibai Dihuang Pills in preventing and treating cisplatin acute kidney injury. Background technique [0002] Cisplatin (Cisplatin, CDDP) is a clinical first-line non-specific antineoplastic drug, mainly used in the treatment of head and neck cancer, lung cancer, ovarian cancer and other solid malignant tumors. Cisplatin can cause cell death through a variety of ways, the most important of which is to interfere with DNA replication synthesis and induce cell death. However, the clinical application of cisplatin has been limited due to serious side effects. Among them, 25-40% of clinical patients will develop kidney disease after injecting cisplatin. The molecular mechanism of cisplatin-induced acute kidney injury is complex, and the existing studies are mainly related to oxidative stress, inflammation, hypoxia, vascular injury, apoptosis and other mechanisms....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61K9/20A61K47/46A61P13/12
Inventor 刘振徐晔陈晓宣郭履倩李昕冉高俊玲王近近向岑滕玉鸥郁彭
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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