Construction and application method of breast cancer prognosis model and storage medium

A construction method and breast cancer technology, applied in the field of breast cancer prognosis model construction, can solve problems such as inability to accurately assess risk stratification to guide treatment strategies

Pending Publication Date: 2022-04-08
MACAU UNIV OF SCI & TECH
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  • Claims
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Problems solved by technology

[0004] The embodiment of the present application provides a breast cancer prognostic model construction and its application method and storage medium, to at least solve the problem in the related art that based on only one feature, it is impossible to accurately evaluate risk stratification and guide treatment strategies

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  • Construction and application method of breast cancer prognosis model and storage medium
  • Construction and application method of breast cancer prognosis model and storage medium
  • Construction and application method of breast cancer prognosis model and storage medium

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Embodiment Construction

[0112] In order to make the purpose, technical solution and advantages of the present application clearer, the present application will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present application, not to limit the present application.

[0113] It should be understood that in the description of the embodiments of the present application, multiple (or multiple) means more than two, greater than, less than, exceeding, etc. are interpreted as not including the original number, and above, below, within, etc. are understood as including the original number. If there are descriptions such as "first", "second", "third", etc., it is only for the purpose of distinguishing technical features, and it cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features o...

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Abstract

The invention relates to a breast cancer prognosis model construction and application method and a storage medium, and the construction method comprises the steps: obtaining a breast cancer training data set, and carrying out the preprocessing of the data of each patient in the breast cancer training data set, and the data of each patient comprises a plurality of features; dividing the breast cancer training data set into different groups based on the plurality of features, the different groups being determined based on infiltration levels of different immune cells; differential expression genes between the different groups are analyzed, candidate genes are obtained through filtering, and the differential expression genes comprise the differential expression genes related to immune infiltration and the differential expression genes participating in a transfer mechanism; and constructing a risk scoring model based on the candidate genes. By integrating immune related gene signals related to metastasis, the prognosis effect of a patient can be evaluated more accurately, and treatment of the patient can be guided.

Description

technical field [0001] The application relates to the construction of a breast cancer prognosis model, its application method and storage medium. Background technique [0002] Cancer has gone through a long human history and is still the leading cause of death. Breast cancer is one of the most common malignant tumors in women worldwide. Breast cancer is also the second most common cause of cancer-related death in women. Although tremendous advances in medicine over the years have reduced mortality, the high heterogeneity of breast cancer still makes prognosis and treatment challenging. [0003] Over the past decade, considerable work has been done to develop prognostic indicators of breast cancer progression. Most (about 80%) breast cancers become invasive, and about 20-30% result in distant metastases after treatment. Metastasis is therefore the deadliest development of breast cancer, drastically reducing long-term survival from 90% to 5%. However, most of the distincti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G16H50/50G16B5/00G06N3/04G06N3/08
Inventor 黄琛
Owner MACAU UNIV OF SCI & TECH
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