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Self-constriction silk protein tissue lifting material and preparation method thereof

A fibroin, self-shrinking technology, applied in medical science, surgery, etc., can solve the problems of not long-lasting lifting effect, high price, and difficult to take out.

Pending Publication Date: 2022-04-12
SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing stress-lifting materials on the market are easy to fall off when buried under the skin, the lifting effect is not long-lasting, and the price is expensive. Moreover, most of the current lifting materials use the inverted tooth structure on the surface to lift the facial tissue. Postoperative infection, this structure will cause a lot of trauma and is not easy to remove after infection

Method used

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  • Self-constriction silk protein tissue lifting material and preparation method thereof
  • Self-constriction silk protein tissue lifting material and preparation method thereof
  • Self-constriction silk protein tissue lifting material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] see figure 1 , figure 1 It is a schematic flow chart of the preparation method of a self-shrinking silk protein tissue lifting material provided in the embodiment of the present application, including the following steps:

[0065] In step S101, a fibroin solution is prepared.

[0066] In step S103, the fibroin solution is transferred to a mold, and placed under a first preset condition for a first preset time to obtain a fibroin film.

[0067] In step S105, the silk protein film is subjected to cross-linking treatment to obtain a cross-linked silk protein film.

[0068] In step S107, stretching treatment is performed on the cross-linked silk protein film.

[0069] In step S109, the stretched cross-linked silk protein film is dried to obtain a self-shrinking silk protein tissue pulling material.

[0070] The applicant found during the experiment that silk is a natural polymer material, and under normal conditions, the macromolecular chains of silk maintain conformati...

Embodiment 2

[0076] The present application can further prepare the self-shrinking silk protein tissue lifting material with heating function on the basis of the preparation steps provided in Example 1. The specific steps of the preparation method in this example are as follows: Figure 4 The following steps are shown:

[0077] In step S401, a fibroin solution is prepared.

[0078] In step S403, the fibroin solution is transferred to a mold, and placed under a first preset condition for a first preset time to obtain a fibroin film.

[0079] In step S405, the silk protein film is subjected to cross-linking treatment to obtain a cross-linked silk protein film.

[0080] In step S407, the fibroin solution is placed in a dialysis bag for dialysis concentration to obtain a concentrated fibroin solution with a concentration of 27-29%.

[0081] In step S409, the concentrated silk protein solution and the gold nanorod solution are mixed according to a preset ratio to obtain a first mixed solution...

Embodiment 3

[0094] The present application can further prepare the self-shrinking silk protein tissue lifting material with antibacterial function on the basis of the preparation steps provided in Example 1. The specific steps of the preparation method in this embodiment are as follows: Figure 6 The following steps are shown:

[0095] In step S601, a fibroin solution is prepared.

[0096] In step S603, the fibroin solution is transferred to a mold, and placed under a first preset condition for a first preset time to obtain a fibroin film.

[0097] In step S605, the silk protein film is subjected to cross-linking treatment to obtain a cross-linked silk protein film.

[0098] In step S607, the fibroin solution is placed in a dialysis bag for dialysis concentration to obtain a concentrated fibroin solution with a concentration of 27-29%.

[0099] In step S609, the concentrated silk protein solution and the antibacterial drug are mixed in a preset ratio to obtain a second mixed solution. ...

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Abstract

The invention relates to a self-constriction silk protein tissue lifting material and a preparation method thereof. The preparation method comprises the following steps: preparing a silk protein solution; transferring the silk protein solution into a mold, and standing for a first preset time under a first preset condition to obtain a silk protein film; carrying out cross-linking treatment on the silk protein membrane to obtain a cross-linked silk protein membrane; carrying out stretching treatment on the cross-linked silk protein membrane; and drying the stretched cross-linked fibroin membrane to obtain the self-constriction fibroin tissue lifting material. The self-constriction silk protein tissue lifting material provided by the embodiment of the invention can realize regulation and control of skin tension through a self-constriction function, and is widely applied to the field of skin tension regulation and control.

Description

technical field [0001] The present application relates to the technical field of material preparation, in particular to a self-shrinking silk protein tissue pulling material and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, the medical beauty industry is developing rapidly, and most of them are skin tension problems. Taking facial skin tightening and lifting as an example, the ideal lifting material should have good biocompatibility and the lifting effect can be maintained for one to two years after implantation, but there is almost no lifting material on the market at present. Material can do it. The existing stress-lifting materials on the market are easy to fall off when buried under the skin, the lifting effect is not long-lasting, and the price is expensive, and most of the current lifting materials use the inverted tooth structure on the surface to lift the facial tissue. Postoperative infection, this s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14
Inventor 陶虎谢亚婷柳克银彭银波
Owner SHANGHAI INST OF MICROSYSTEM & INFORMATION TECH CHINESE ACAD OF SCI