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Application of PGLa in improving sensitivity of bacteria to antibiotics and delaying generation of bacterial drug resistance

A technology of antibiotics and bacteria, which is applied in the field of medicine, can solve the problem that the synergistic effect of inhibiting drug-resistant bacteria is difficult to determine, and achieve the effects of delaying the emergence of bacterial resistance, high safety and operability, and delaying the emergence of drug resistance

Pending Publication Date: 2022-05-06
NORTHWEST A & F UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, when PGLa or antibiotics are used alone, higher concentrations are required to inhibit the growth of drug-resistant bacteria, and the synergistic effect of the combination of the two on inhibiting drug-resistant bacteria is still difficult to determine

Method used

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  • Application of PGLa in improving sensitivity of bacteria to antibiotics and delaying generation of bacterial drug resistance
  • Application of PGLa in improving sensitivity of bacteria to antibiotics and delaying generation of bacterial drug resistance
  • Application of PGLa in improving sensitivity of bacteria to antibiotics and delaying generation of bacterial drug resistance

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Embodiment Construction

[0032] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the following examples are only used to explain the present invention, not to limit the protection scope of the present invention.

[0033] (1) Determination of drug resistance of Staphylococcus aureus

[0034] Staphylococcus aureus is a common food-borne pathogen that widely exists in the natural environment. Staphylococcus aureus can produce enterotoxin under appropriate conditions, causing food poisoning.

[0035] The experimental steps for determining the minimum inhibitory concentration of Staphylococcus aureus to various antibiotics are as follows:

[0036] 1. Strain selection: Staphylococcus aureus Mu50 was selected for the experiment, and Mu50 is a strain of multidrug-resistant Staphylococcus aureus isolated from a patient.

[0037] 2. Preparation of antibacterial drugs:

[0038]Chloramphenicol and tetrac...

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Abstract

The invention discloses application of PGLa in improving sensitivity of bacteria to antibiotics and delaying generation of bacterial drug resistance. Through combined medication of the polypeptide PGLa and the antibiotics, the sensitivity of drug-resistant bacteria to the antibiotics is improved, generation of bacterial drug resistance is delayed, and the polypeptide PGLa has a better effect and higher safety and operability in overcoming the bacterial drug resistance in drug application.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the combined medicine of polypeptide PGLa and antibiotics, and the application of polypeptide PGLa in improving the sensitivity of bacteria to antibiotics and delaying the generation of bacterial drug resistance. Background technique [0002] Antibiotic-resistant bacteria seriously endanger human health. According to the U.S. Centers for Disease Control and Prevention, more than 2 million people in the U.S. are infected with drug-resistant bacteria every year, causing at least 23,000 deaths. The World Health Organization predicts that by 2050, deaths from drug-resistant infections could reach 10 million people per year. In animal husbandry, "anti-antibiotics are prohibited at the feed end and limited at the breeding end" has been fully implemented. Therefore, there is an urgent need to develop new antibacterial drugs to save the curative effect of antibiotics. [0003] The comb...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K45/06A61P31/04
CPCA61K38/1703A61K45/06A61P31/04
Inventor 薛虎平郑良俊辛清婷赵丽丽王晨黄建国薛雪梅
Owner NORTHWEST A & F UNIV
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