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METTL16 inhibitors and uses thereof

A technology for cancer and patients, applied in the field of METTL16 inhibitors and their uses, can solve the problem of limited significance of RNA modification

Pending Publication Date: 2022-05-17
CITY OF HOPE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While these treatments have focused on DNA methylation, it is known that RNA residues can also be modified, but RNA modifications have limited significance

Method used

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  • METTL16 inhibitors and uses thereof
  • METTL16 inhibitors and uses thereof
  • METTL16 inhibitors and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0391] Embodiment 1. A compound of formula (B) or a pharmaceutically acceptable salt thereof.

Embodiment approach 2

[0392] Embodiment 2. A compound of formula (C) or a pharmaceutically acceptable salt thereof.

Embodiment approach 3

[0393] Embodiment 3. A pharmaceutical composition comprising a compound according to embodiment 1 or 2 and a pharmaceutically acceptable excipient.

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Abstract

The present disclosure provides, inter alia, METTL16 inhibitors and methods of treating cancers that overexpress METTL16.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Application Serial No. 62 / 889,431, filed August 20, 2019, the disclosure of which is incorporated herein by reference in its entirety. [0003] Statement Regarding Invention Rights in Federally Sponsored Research and Development [0004] This invention was made with Government support under Grant Numbers CA214965 and CA236399 awarded by the National Institutes of Health. The government has certain rights in this invention. Background technique [0005] Many advances in cancer therapy have focused on the DNA methylation process, including the discovery of mutations in the enzymes that methylate DNA (for example, DNMT3A mutations) and the DNA demethylation process (for example, TET2 and IDH1 / 2 mutations). Anticancer agents, such as DNA methyltransferase inhibitors (eg, decitabine and 5-azacitidine), are known to treat cancer by affecting DNA methylation. While these treatments have...

Claims

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Application Information

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IPC IPC(8): C07D487/04A61K31/517A61P35/00
CPCC07D487/04A61P35/00A61K31/519
Inventor 陈建军邓晓岚韩丽李红志苏瑞
Owner CITY OF HOPE