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Preparation method of phenolic amide peptide and anti-inflammatory and bacteriostatic traditional Chinese medicine composition formed by phenolic amide peptide

A composition, phenolamide technology, applied in the field of biomedicine to achieve the effect of soothing oral inflammation

Pending Publication Date: 2022-06-07
上海朗泰凯尔生物技术有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there is no good topical drug for the treatment of oral ulcers clinically

Method used

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  • Preparation method of phenolic amide peptide and anti-inflammatory and bacteriostatic traditional Chinese medicine composition formed by phenolic amide peptide
  • Preparation method of phenolic amide peptide and anti-inflammatory and bacteriostatic traditional Chinese medicine composition formed by phenolic amide peptide
  • Preparation method of phenolic amide peptide and anti-inflammatory and bacteriostatic traditional Chinese medicine composition formed by phenolic amide peptide

Examples

Experimental program
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Embodiment 1

[0028] The present embodiment provides a method for preparing a separated and purified phenolamide peptide, comprising the following steps:

[0029] 1) Separation method of Lycium barbarum phenolamide peptides.

[0030] Mix 50 g of commercially available Lycium barbarum (dry weight) and 500 mL of water evenly, extract the mixture by ultrasonic for 30 minutes, centrifuge at 5000 g for 10 minutes, ultrasonic extraction and centrifugation, and repeat 3 times. Taking the supernatant, freeze-drying at low temperature in vacuum, analyzing by chromatography and preparing by HPLC to obtain the wolfberry phenolamide peptide. Lycium barbarum phenolamide peptide, the structural formula of the wolfberry phenolamide peptide is: The molecular formula is C 30 H 33 N 3 O 8 .

[0031] The preparation conditions of the above-mentioned preparative HPLC are: take 0.1v% trifluoroacetic acid aqueous solution as mobile phase A, take 0.1v% trifluoroacetic acid solution in acetonitrile as mobil...

Embodiment 2

[0084] The difference between this example and Example 1 is that in this embodiment, the wolfberry and water are mixed evenly, the mass ratio of the wolfberry and the water is 1:(10-50), and the quality of the active extract of traditional Chinese medicine and the wolfberry amide peptide is The ratio is (1~100):(1~100). The active extracts of traditional Chinese medicines include two or more combinations of wolfberry active extracts, pineapple active extracts, blueberry active extracts, and white peach active extracts. The mass ratio of wolfberry active extract, pineapple active extract, blueberry active extract and white peach active extract is (1-10):(1-10):(1-10):(1-10).

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Abstract

The invention belongs to the technical field of biomedicine, and particularly relates to a preparation method of phenolic amide peptides and an anti-inflammatory and bacteriostatic traditional Chinese medicine composition formed by the phenolic amide peptides. Comprising the following steps: uniformly mixing wolfberry with water according to a mass ratio of 1: (10-50), carrying out ultrasonic extraction and centrifugation on the mixed solution, carrying out vacuum low-temperature freeze-drying on the supernatant, and then carrying out chromatographic separation and HPLC preparation to obtain the wolfberry phenolic amide peptide. The traditional Chinese medicine composition for resisting inflammation and inhibiting bacteria is prepared from the traditional Chinese medicine active extract and the amide peptide compound, and has the effects of relieving oral inflammations such as oral ulcer, inhibiting formation of streptococcus mitis and streptococcus mutans biological membranes, improving the anti-inflammation and anti-bacterial effects and the like. The invention also relates to an application in oral hygiene products and oral health products for preventing and treating dental caries, periodontitis and other oral problems.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a preparation method of a phenolamide peptide and an anti-inflammatory and antibacterial traditional Chinese medicine composition. Background technique [0002] Oral ulcers are a common oral mucosal disease. The main causes of oral ulcers are local trauma, changes in food, and hormone levels. Patients generally have obvious pain, which affects eating. In addition, the occurrence and development of oral ulcers are closely related to inflammation. So far, there is no good topical drug for the treatment of oral ulcers. [0003] Dental caries is a disease that causes the chronic and progressive destruction of the hard tissue of the tooth under the influence of various factors, mainly bacteria. Dental caries is listed by WHO as one of the three major chronic non-communicable diseases that endanger human health, second only to cancer and cardiovascular diseases. Ther...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/083C07K1/14C07K1/16A61K38/06A61P31/04A61K36/815A61K36/88A61K36/45A61K36/736
CPCC07K5/0806A61K38/06A61K36/815A61K36/88A61K36/45A61K36/736A61P31/04A61K2300/00Y02A50/30
Inventor 刘杰王尔一郑曼张玉波杨欣欣罗丹张健润
Owner 上海朗泰凯尔生物技术有限公司
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