Preparation method and application of drug-loaded slow-release spider silk protein membrane

Abstract

The invention relates to a preparation method and application of a drug-loaded slow-release spider silk protein film. The medical nursing consumable device is suitable for household nursing and/or inter-diagnosis treatment of the dentin sensitive patient. According to the invention, a pre-film-forming drug loading method for blending a Kangfuxin drug and/or other desensitizers and natural degummed spider threads in a solvent is used, and the natural spider threads with good biocompatibility are prepared into a biocompatible sustained-release film loaded with the Kangfuxin drug and/or other desensitizers; kangfuxin drugs and/or other desensitizer drug molecules embedded in pores of the biological material skeleton can be continuously and slowly released, so that the problems of insufficient burst release and insufficient action time of desensitization toothpaste are solved. The desensitization membrane can be attached to teeth and can also be stuffed between the teeth and gingival seams, or the membrane is stuffed into a periodontal pocket, so that the effects of desensitization and repair nursing for a long time are achieved. The drug-loaded sustained-release membrane disclosed by the invention can effectively improve the rapidness, convenience and effectiveness of administration, dressing change and nursing of a patient with dentin sensitivity.

Description

technical field [0001] The invention relates to the field of medical care consumables, in particular, the invention relates to the preparation of a drug-loaded slow-release spidroin film and its application in the preparation of dentin-sensitive medical care consumables. The medical care consumable device is suitable for home care or out-of-office treatment of patients with dentin sensitivity. Background technique [0002] Dentin sensitivity refers to the short and sharp pain caused by exposed dentin to external stimuli, including temperature stimuli, osmotic pressure stimuli, chemical stimuli, air blowing stimuli, mechanical stimuli, etc. In 2008, a survey by the Chinese Stomatological Association found that among the 8,000 survey samples, 40.7% reported dentin hypersensitivity, while the attack rate of those diagnosed with dentin hypersensitivity reached 29.7%. The average number of dentin hypersensitivity teeth per capita was 1.4, and the incidence rate of dentin hyperse...

AI Technical Summary

Problems solved by technology

[0008] At present, biocompatible slow-release film-forming materials at home and abroad are roughly divided into natural and synthetic materials. However, there are few film-forming materials for natural spider silk used in slow-release films. Compatibility is second to none in the world, but whether pure spider silk can curl up and self-assemble into a biological skeleton under certain conditions; whether the formed spider silk biocompatible film can be loaded with drug molecules, and how to restore new drugs And / or the desensitizing agent is effectively mixed with the spider silk, so that the self-assembled spider silk bioprotein film can wrap the effective drug molecules and / or desensitizing active molecules in Kangfuxin and release them slowly in the oral environment. There is no research conclusion , which is a key common technology that needs to be solved urgently in the industry

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