Preparation method and application of spider thread drug-loaded oral sustained-release membrane
The technology of slow-release film and spider silk is applied in the field of preparation of spider silk drug-loaded oral slow-release film, which can solve the problems of rare film-forming materials, waste of drugs on ulcer surfaces, etc., and achieves supplementation of immune-enhancing molecules and good safety. , good biocompatibility
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Embodiment 1
[0048] Example 1: Preparation of drug-loaded material blank matrix spidroin film
[0049] This embodiment provides a method for preparing a drug-loaded material blank matrix spidroin film. The Jingzhao tasseled spider silk used in the experiment came from Hainan Spider King Biotechnology Co., Ltd.
[0050] 1.1 Preparation of drug-loaded material blank matrix spidroin protein solution: Weigh 100mg of degummed Jingzhao tassel spider silk, cut it into pieces and place it in a 1000mL round bottom flask; measure 600mL of hexafluoroisopropanol (HFIP) Pour the solution into a round-bottomed flask, place it on a heat-collecting magnetic stirrer, heat it to 50°C and reflux for 12 hours to dissolve it; filter the dissolved spidroin solution while it is hot with an 800-mesh stainless steel metal filter, Obtain pure drug-loaded material blank matrix spidroin filtrate. The filtrate was placed in a round-bottomed flask and heated to 60° C. to condense and reflux to recover the solvent, an...
Embodiment 2
[0052] Example 2: Preparation of drug-loaded spidroin protein rehabilitation drug extract film
[0053] This embodiment provides a preparation method of drug-loaded spidroin protein rehabilitation drug extract film. The Jingzhao tasseled spider silk used in the test comes from Hainan Spider King Biotechnology Co., Ltd. In this example, the new rehabilitation drug refers to the new rehabilitation drug extract (that is, the raw material of the new rehabilitation liquid), which is provided by Sichuan Good Doctor Panxi Pharmaceutical Co., Ltd. provided by the company.
[0054] 2.1 Preparation of drug-loaded material blank matrix spidroin solution: Weigh 800 mg of degummed Jingzhao tassel spider silk, cut it into pieces and dissolve it in 2400 mL of hexafluoroisopropanol solution, and place the dissolving device in a heat collecting type On a magnetic stirrer, heat in a 60°C water bath and reflux for 10 hours to dissolve it; filter the dissolved spidroin solution while it is hot w...
Embodiment 3
[0057] Example 3: Preparation of drug-loaded spidroin inosine film
[0058] This embodiment provides a method for preparing a drug-loaded spidroin inosine film. The Jingzhao tasseled spider silk used in the experiment was from Hainan Spider King Biotechnology Co., Ltd., and the inosine was purchased from Shanghai Yuanye Biotechnology Co., Ltd.
[0059] 3.1 Preparation of drug-loaded material blank matrix spidroin solution: Weigh 500 mg of degummed Jingzhao tassel spider silk and dissolve it in 2500 mL of hexafluoroisopropanol solution, heat to 65°C with magnetic stirring and reflux for 8 hours to dissolve; Filter the dissolved spidroin solution while hot with a 200-mesh stainless steel metal filter to obtain a pure drug-loaded material blank matrix spidroin filtrate. The obtained spidroin filtrate was placed in a round-bottomed flask, heated, condensed and refluxed to recover the solvent, the recovery temperature was controlled at 65° C., and concentrated to obtain 50 mL of d...
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