Preparation method and application of spider thread drug-loaded oral sustained-release membrane

Abstract

The invention relates to a preparation method and application of a spider thread drug-loaded oral sustained-release membrane, in particular to a pre-membrane-forming drug-loading method by blending a drug solution or a drug composition with a natural spider thread solution, the loaded drug is inosine, a Kangfuxin drug or a drug composition of the inosine and the Kangfuxin drug, and the spider thread is Jingzhaochbrachys jingzhaochys jingzhaochys jingzhaochys jingzhaochys jingzhaochys jingzhaochys jingzhaochys. The spider thread drug-loaded oral sustained-release membrane prepared by the method is good in biocompatibility, can successfully load Kangfuxin drug and/or inosine drug molecules and slowly release the drug, the drug release time of the spider thread drug-loaded oral sustained-release membrane in artificial saliva and the oral cavity of a human body is not less than 4 hours, and the spider thread drug-loaded oral sustained-release membrane is not degraded in the artificial saliva for 160 hours and is degraded in artificial gastric juice for 24 hours; the spider-thread medicine-carrying oral sustained-release membrane has certain tensile strength and adhesive force, can be applied to oral buccal membrane parts, gingiva and sublingual parts, is convenient to carry, use and replace in daily life, does not influence the safety of oral mucosa, and is suitable for home nursing and inter-diagnosis treatment of various oral ulcers.

Description

technical field [0001] The invention relates to the field of medical nursing consumables, in particular, the invention relates to a preparation method and application of a spider silk drug-loaded oral sustained-release film. The medical care consumable device is suitable for home care and out-of-office treatment of oral ulcers such as radiation stomatitis and chemotherapeutic stomatitis. Background technique [0002] One of the side effects of tumor radiotherapy and chemotherapy is recurrent and refractory oral ulcers. Oral ulcers caused by radiotherapy refer to the inflammatory response of oral mucosal tissue in patients with malignant tumors caused by radiotherapy, which is the severe oral mucosal injury referred to by radiotherapy ( Ahadian H., et al., Oral complications of the oromaxillofacial arearadiotherapy, Asian Pacific J Cance Prevent Apjcp, 2017,18(3):721-725; National Health Commission, China Health Statistical Yearbook 2018, published by Peking Union Medical Col...

AI Technical Summary

Problems solved by technology

However, although Kangfuxin liquid alone or in combination has a significant effect on the prevention and treatment of oral diseases, its liquid dosage forms have natural defects: wet compresses, gargles, smears, oral administration, spraying, or oral administration and application Combined administration method; with the physiological swallowing action in the oral cavity, a drug layer formed on the surface interface of the buccal mucosa, around the tongue, and periodontal gums will be gradually washed away by the saliva secreted by the salivary glands, and the new drug solution will be restored It is difficult for the active ingredients in the drug to remain in the patient's ulcer surface stably for a long time, thus causing a lot of waste of drugs for the treatment of ulcer surface

[0013] At present, biocompatible slow-release film-forming materials at home and abroad are roughly divided into natural and synthetic materials. However, natural spider silk fibroin is rarely used in film-forming materials for slow-release films. The reason is that although spider silk The biocompatibility of spider silk is second to none in the world, but whether pure spider silk can curl up and self-assemble into a biological skeleton under specific conditions, and whether the formed spider silk biocompatible film can be loaded with drug molecules, and how to New rehabilitation drugs and inosine drug molecules are effectively mixed with spider silk, so that the self-assembled spider silk bioprotein film can wrap effective drug molecules such as inosine in new rehabilitation drugs and release them slowly in the oral environment. There is no research conclusion yet , which is a key common technology that needs to be solved urgently in the industry

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