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A bioadhesive slow-release oral ulcer gel and its preparation method

A technique for oral ulcers and bioadhesion, applied to medical preparations containing non-active ingredients, medical preparations containing active ingredients, organic active ingredients, etc., can solve problems such as unfavorable drug efficacy and side effects of magnesium stearate, and achieve Prolong the time of sustained release, promote regeneration, and improve the uniformity of dispersion

Active Publication Date: 2020-02-21
HARBIN QIANBAINA BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But magnesium stearate has certain side effect, is unfavorable for the exertion of drug effect

Method used

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  • A bioadhesive slow-release oral ulcer gel and its preparation method
  • A bioadhesive slow-release oral ulcer gel and its preparation method
  • A bioadhesive slow-release oral ulcer gel and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A bioadhesive slow-release oral ulcer gel, taking the preparation of 100g as an example, is made of the following raw materials:

[0055]

[0056] The preparation method of slow-release oral ulcer gel comprises the steps:

[0057] 1) Take castor oil, macrogol 200, propylene glycol, glycerin, and medical vaseline in the prescribed amount, mix and stir at a stirring speed of 30 r / min, at a temperature of 65°C, and for 30 minutes to obtain substance A;

[0058] 2) Add the formula amount of sodium carboxymethylcellulose and chitosan to substance A, and stir homogeneously under vacuum conditions, the vacuum degree is -0.03MPa, the rotation speed is 1000r / min, the time is 60min, and the temperature is 65°C , get substance B;

[0059] 3) Add formula methylparaben, ethylparaben and menthol in the substance B, and stir homogeneously under vacuum conditions, the vacuum degree is -0.03MPa, the rotation speed is 1000r / min, and the time is 10min. The temperature is 65°C. After ...

Embodiment 2

[0061] A bioadhesive slow-release oral ulcer gel, taking the preparation of 100g as an example, is made of the following raw materials:

[0062]

[0063]

[0064] The preparation method of slow-release oral ulcer gel comprises the steps:

[0065] 1) Take the liquid paraffin, glycerol, and medical vaseline in the prescribed amount, mix and stir, the stirring speed is 60r / min, the temperature is 75°C, and the time is 60min, to obtain substance A;

[0066] 2) Add formula amount of hydroxypropyl methylcellulose and chitosan to substance A, stir homogeneously under vacuum condition, vacuum degree is -0.07MPa, speed is 3000r / min, time is 90min, temperature is 75 ℃, to obtain substance B;

[0067] 3) Add the formulated amount of sodium benzoate, sucrose, and menthol to substance B, stir homogeneously under vacuum conditions, the vacuum degree is -0.07MPa, the speed is 3000r / min, the time is 30min, the temperature is 75°C, After stirring, it is filled at a constant temperature...

Embodiment 3

[0069] A bioadhesive slow-release oral ulcer gel, taking the preparation of 100g as an example, is made of the following raw materials:

[0070]

[0071] The preparation method of slow-release oral ulcer gel comprises the steps:

[0072] 1) Take polysorbate, polyethylene glycol 200, propylene glycol, and glycerol in the formula amount, mix and stir, the stirring speed is 45r / min, the temperature is 70°C, and the time is 45min, to obtain substance A;

[0073] 2) Add polyvinyl alcohol, hydroxypropyl methylcellulose and chitosan in the formula amount to substance A, stir homogeneously under vacuum conditions, the vacuum degree is -0.05MPa, the rotating speed is 2000r / min, and the time is 75min , the temperature is 70°C, and substance B is obtained;

[0074] 3) Add the formula amount of benzyl alcohol and citron syrup to the substance B, and stir homogeneously under vacuum condition, the vacuum degree is -0.05MPa, the rotation speed is 2000r / min, the time is 20min, the tempera...

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Abstract

The invention relates to the field of pharmaceutical preparations, in particular to a slow-release oral ulcer gel with bioadhesiveness and a preparation method thereof. The oral ulcer gel is preparedby the following raw materials by mass percentage: 10-25% of a sustained release material, 5-20% of a dispersant, 0.1-0.5 % of a bacteriostatic agent, 0.5-1% of a flavoring agent, and the balance of agel plasticizer. The oral ulcer gel has the advantages of high adhesion strength, long adhesion time, and good sustained release effect.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a bioadhesive slow-release oral ulcer gel and a preparation method thereof. Background technique [0002] Oral ulcer, commonly known as "oral sore", is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, tongue belly, buccal mucosa, vestibular groove, soft palate and other parts. The mucosa in these parts lacks stratum corneum. or poor keratosis. There are many reasons for oral ulcers, such as low autoimmunity; vitamin deficiency; individual wound healing barriers; various viruses invade the oral cavity; low levels of white blood cells in the blood can cause oral ulcers. Oral ulcers are not a serious disease, but they occur in people of all age groups. The pain is severe when it occurs, and the local burning pain is obvious. It is difficult to cure and recurs. In severe cases, it will affect eating and talking,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/192A61K31/045A61K31/235A61K47/36A61K47/38A61K47/32A61K47/40A61K47/06A61K47/44A61K47/26A61K47/10A61K47/46A61K47/42A61P1/02
CPCA61K9/006A61K9/06A61K31/045A61K31/192A61K31/235A61K47/06A61K47/10A61K47/26A61K47/32A61K47/36A61K47/38A61K47/40A61K47/42A61K47/44A61K47/46A61P1/02A61K2300/00
Inventor 高纳新
Owner HARBIN QIANBAINA BIOPHARM
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