N-heterocyclic carbene-gold-palladium alloy nanoparticles as well as preparation method and application thereof

A nitrogen heterocyclic carbene, nanoparticle technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as application limitations, and achieve the effects of increasing curative effect, excellent water solubility, and promoting stability

Pending Publication Date: 2022-06-24
WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The dispersion of nanoparticles in the aqueous system is the basic requirement for their use in the biological field. Although a large number of NHC-modified metal nanoparticles have been developed, most of them are hydrophobic, and their applications in the biomedical field restricted

Method used

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  • N-heterocyclic carbene-gold-palladium alloy nanoparticles as well as preparation method and application thereof
  • N-heterocyclic carbene-gold-palladium alloy nanoparticles as well as preparation method and application thereof
  • N-heterocyclic carbene-gold-palladium alloy nanoparticles as well as preparation method and application thereof

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Embodiment 1

[0044] A preparation method of nitrogen heterocyclic carbene Au-Pd alloy nanoparticles (NHC-AuPd nanoparticles), the specific steps are as follows:

[0045] (1) Preparation of compound 1: 6.7 mol of benzimidazole was added to 20 mL of ethanol solution containing 6.7 mmol of KOH, stirred for 1 hour, and 6.7 mmol of 4-(2-chloroethyl)morpholine was added dropwise. The reaction was carried out at 76°C for 8 hours. The ethanol was spin-dried and finally purified by silica gel column chromatography with methanol:dichloromethane volume ratio of 1:20 to obtain compound 1, which was in CDCl 3 The H NMR spectrum in figure 1 ;

[0046](2) Preparation of compound 2: 5 mmol of tetraethylethylene glycol monomethyl ester was added to 2.5 mL of tetrahydrofuran, stirred in an ice bath, and 2.5 mL of sodium hydroxide solution containing 0.6 g was added. Finally, 7.5 mmol of p-toluenesulfonyl chloride dissolved in 1.5 mL of tetrahydrofuran was added dropwise, and the reaction was carried out ...

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Abstract

The invention discloses N-heterocyclic carbene-gold-palladium alloy nanoparticles as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. Comprising the following steps: adding N-heterocyclic carbene and potassium tert-butoxide into an organic solvent, stirring in an inert atmosphere, then adding a gold ion source and a palladium ion source for reaction, transferring into water after reaction, heating until boiling, then adding a reducing agent for continuous reaction, and obtaining the N-heterocyclic carbene-gold-palladium alloy nanoparticles after the reaction is completed. According to the invention, a novel NHC structure is firstly designed, and the structure has excellent water solubility, can promote the in-vivo stability and water dispersibility of Au-Pd alloy nanoparticles, and enables the Au-Pd alloy nanoparticles to have pH responsiveness. The prepared NHC-AuPd nano particles have strong photo-thermal properties, and can realize effective photo-thermal sterilization.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a nitrogen heterocyclic carbene-gold palladium alloy nanoparticle and a preparation method and application thereof. Background technique [0002] Nanomaterials have been widely used in biomedicine, such as detection, therapy (drug delivery), and disease imaging, due to their high specific surface area and easy surface functionalization. Inorganic nanoparticles exhibit unique physical properties (such as magnetic, electrical, and plasmonic properties) that enable them to have photothermal and photodynamic therapeutic effects under excitation by near-infrared light. Among them, gold (Au) and palladium (Pd) nanoparticles have unique optical, electrical and magnetic properties and can be used for surface plasmon resonance, fluorescence, electrochemistry, supramolecular and molecular recognition. Many biomacromolecules are similar in nanometer size and therefore have exc...

Claims

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Application Information

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IPC IPC(8): C07F19/00C07D235/14B82Y5/00B82Y40/00A61K41/00A61P31/04
CPCC07F19/00C07D235/14B82Y40/00B82Y5/00A61K41/0057A61P31/04
Inventor刘勇伍凡詹益周李圆凤王娅然
OwnerWENZHOU INST UNIV OF CHINESE ACAD OF SCI