Active ingredient composition derived from dendrobium officinale and gynostemma pentaphylla and application of active ingredient composition

A technology of Gynostemma pentaphyllum and composition, which is applied in the application field of cosmetics and skin care products, can solve the problems of reducing skin immunity, mucous membrane irritation, complicated process, etc., and achieve the effect of reducing skin immunity

Pending Publication Date: 2022-07-08
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] Based on this, the main purpose of the present invention is to provide a pharmaceutical composition of active ingredients derived from Dendrobium officinale and Gynostemma pentaphyllum, to solve the common active ingredients in the prior art that are not clear, cosmetics and skin care products are prone to allergic reactions, and the process is complicated And the problem of high cost, mucous membrane irritation, easy to produce drug resistance, lower skin immunity and large toxic and side effects

Method used

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  • Active ingredient composition derived from dendrobium officinale and gynostemma pentaphylla and application of active ingredient composition
  • Active ingredient composition derived from dendrobium officinale and gynostemma pentaphylla and application of active ingredient composition
  • Active ingredient composition derived from dendrobium officinale and gynostemma pentaphylla and application of active ingredient composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0142] The preparation process of Erianin

[0143] Take an appropriate amount of Dendrobium officinale medicinal materials, add 10-12 times the volume of 70%-95% ethanol for reflux extraction for 1-3 hours, filter to obtain a filtrate, recover the ethanol until there is no alcohol smell, add an equal volume of ethyl acetate for extraction, The ethyl acetate was recovered to obtain an extract, and the ethyl acetate extract was separated by silica gel column chromatography, eluted with a ratio of n-hexane-ethyl acetate 3:1-5:1, and recrystallized to obtain Erianin.

[0144] Structural identification of Erianin

[0145]

[0146] 1 H-NMR (400MHz, CDCl 3)δ: 6.81(1H,d,J=2.0Hz,H-2),6.72(1H,d,J=8.2Hz,H-5),6.63(1H,dd,J=8.2,2.0Hz,H- 6),6.35(2H,s,H-2',6'),3.84(3H,s,-OCH 3 -4),3.82(9H,s,-OCH 3 -3',4',5'),2.80(4H,s,H-a,a'),5.64(1H,s,-OH); 13 C-NMR (100MHz, CDCl 3 )δ: 153.2, 145.3, 144.7, 137.5, 136.4, 135.2, 119.5, 114.4, 110.4, 105.3, 60.8, 56.2, 38.3, 37.3.

[0147] Preparatio...

Embodiment 1

[0153] Example 1: Weigh 1 part of Erianin and 1 part of Gypensapogenin A, respectively, and mix them evenly to prepare Composition 1.

Embodiment 2

[0154] Example 2: 1 part of Erianin and 2 parts of Gypensapogenin A were respectively weighed and mixed evenly to prepare Composition 2.

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Abstract

The invention provides an active ingredient composition derived from dendrobium officinale and gynostemma pentaphylla and application of the active ingredient composition. The composition comprises a compound as shown in a formula I or a pharmaceutically acceptable solvate thereof and gynostemma pentaphyllum secondary saponin, wherein the weight ratio of the compound as shown in the formula I to the gynostemma pentaphyllum secondary saponin is (1-10): (1-10). The two components in the composition have synergistic whitening activity, and the composition is safe and reliable to human bodies, free of toxic and side effects and free of irritation to mucous membranes, and can be used for preparing whitening cosmetics or skin care products, such as face cream, facial masks, hand cream or facial cleanser.

Description

technical field [0001] The invention relates to the technical field of cosmetics and skin care products, in particular to an active ingredient composition derived from Dendrobium officinale and Gynostemma pentaphyllum and its application in cosmetics and skin care products. Background technique [0002] At present, with the continuous improvement of people's living standards, people's demand for cosmetics and skin care products that promote skin health and whiteness is getting higher and higher. However, people are affected by various factors such as their own age, increased life pressure, long-term use of electronic products and outdoor ultraviolet radiation, improper application of cosmetics and other factors, which lead to the easy deposition of melanin in the skin. Different types of pigmentation spots such as freckles, chloasma and sunburn are easy to appear on the face of people, which seriously affects people's external image. In order to meet the needs of people to i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K31/09A61P17/00A61P17/04A61P29/00A61K8/63A61K8/34A61Q19/00A61Q19/02A61Q19/08A61Q19/10
CPCA61K31/58A61K31/09A61P17/00A61P17/04A61P29/00A61K8/63A61K8/347A61Q19/00A61Q19/02A61Q19/08A61Q19/10A61K2800/782A61K2800/592A61K2300/00Y02A50/30
Inventor 何芋岐谭道鹏鲁艳柳秦琳张倩茹杨洲陆安静吴迪
Owner ZUNYI MEDICAL UNIVERSITY
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