Application of polypeptide in preparation of product for promoting skin wound healing

A technology for skin wounds and products, applied in the field of biomedicine, can solve the problems of expensive protein growth factors, low biological activity of small molecular compounds, and easy to cause hypertrophic scars, etc., to promote skin wound healing, high yield, and low cost Effect

Pending Publication Date: 2022-07-22
HANGZHOU HUIBO SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The first purpose of the present invention is to provide the application of a polypeptide in the preparation of skin wound healing products to alleviate the relatively low and unstable biological activity of small molecular compounds in the prior art; protein growth factors are expensive and have strict storage conditions. Technical problems prone to hypertrophic scarring

Method used

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  • Application of polypeptide in preparation of product for promoting skin wound healing
  • Application of polypeptide in preparation of product for promoting skin wound healing
  • Application of polypeptide in preparation of product for promoting skin wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] This example provides a study on the healing effect of a polypeptide on acute skin wounds. The amino acid sequence of polypeptide Hst1-MAD is SHREFPFYGDYGS (SEQ ID No. 1), and the healing effect of 0.01 μM Hst1-MAD on acute skin wounds is investigated. The specific method is as follows:

[0053] Three C57 mice were anesthetized by intraperitoneal injection of 1% sodium pentobarbital (5ml / kg). Under anesthesia, the dorsal hair of each mouse was carefully shaved and disinfected with iodophor. A circular full-thickness wound of 1 cm was made in the dorsal region of each mouse with a punch biopsy instrument. 0.01 μM Hst1-MAD was applied to the wounds at a dose of 0.5 ml per wound per day until complete healing.

Embodiment 2

[0055] This example provides a study on the healing effect of polypeptides on acute wounds. The difference from Example 1 is that the concentration of Hst1-MAD is 0.1 μM, and the rest of the steps are the same as those in Example 1, which will not be repeated here.

Embodiment 3

[0057] This example provides a study on the healing effect of polypeptides on acute wounds. The difference from Example 1 is that the concentration of Hst1-MAD is 1 μM, and the rest of the steps are the same as those in Example 1, which will not be repeated here.

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Abstract

The invention relates to the technical field of biological medicine, in particular to application of polypeptide in preparation of a product for promoting skin wound healing. The polypeptide provided by the invention is Hst 1-MAD, and the amino acid sequence of the polypeptide is SHREFPFYGDYGS. The Hst 1-MAD promotes wound closure, reepithelization, collagen deposition, angiogenesis and expression of tight junction protein, and remarkably promotes skin wound healing. Meanwhile, the Hst1-MAD actively regulates the conversion from M1 to M2 macrophages and up-regulates an Nrf2 / NQO1 axis, so that a good environment is created for wound healing. The polypeptide provides a new effective substance for preparing a product for promoting skin wound healing.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of polypeptides in the preparation of products for promoting skin wound healing. Background technique [0002] Existing wound healing drugs are mainly divided into two categories: small molecule compounds (such as deferoxamine) and protein growth factors (such as epidermal growth factor). However, these drugs have their own limitations in clinical application. For example, the biological activity of small-molecule compounds is relatively low and unstable, while protein-based growth factors are expensive, require strict storage conditions, and are prone to cause hypertrophic scarring. [0003] In contrast, peptides are a unique class of bioactive agents that promote tissue regeneration. In humans, more than 7000 naturally occurring peptides have been identified as hormones, neurotransmitters, growth factors, ion channel ligands or anti-infective drugs to modu...

Claims

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Application Information

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IPC IPC(8): C12N5/0786A61K38/18A61P17/02A61K8/64A61Q19/00C12Q1/02
CPCC12N5/0645A61K38/18A61P17/02A61K8/64A61Q19/00G01N33/502G01N33/5055C12N2501/119
Inventor 卢云宇雷肖璇程柳行行吴刚吴丽勇
Owner HANGZHOU HUIBO SCI & TECH CO LTD
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