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Humanized antibodies against chemokine-like receptor 1 and therapeutic uses thereof

An antibody and receptor technology, applied in the field of immunotherapy, can solve problems such as difficulty in producing antibodies

Pending Publication Date: 2022-07-22
OSE IMMUNOTHERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to this, it has been difficult to generate antibodies that specifically target G protein-coupled receptors

Method used

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  • Humanized antibodies against chemokine-like receptor 1 and therapeutic uses thereof
  • Humanized antibodies against chemokine-like receptor 1 and therapeutic uses thereof
  • Humanized antibodies against chemokine-like receptor 1 and therapeutic uses thereof

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Embodiment Construction

[0082] The present invention relates to a CMKLR1 agonist with resolvin E1-like ability for use in the treatment of inflammatory conditions in patients, especially inflammatory conditions in which the resolution phase of inflammation is delayed or interrupted, especially in chronic inflammation, In particular the agonist is selected from the group consisting of antibodies or antigen-binding fragments thereof, peptides, polypeptides and proteins.

[0083] In the following description, unless mentioned to the contrary, a CMKLR1 agonist with resolvin E1-like capacity may be referred to as the "the agonist" or "an agonist"; both terms Both include antibodies or antigen-binding fragments thereof (also known as anti-CMKLR1 antibodies), proteins, peptides or polypeptides; the term "compound" or "anti-CMKLR1 compound" may also be used in the description below as an "agonist" (of the invention). " is synonymous with ", thereby including antibodies or antigen-binding fragments thereof (a...

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PUM

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Abstract

The present invention provides humanized anti-CMKLR1 compounds which have agonist ability for the interaction between Resolvin E1 and CMKLR1, and their use in the treatment or prevention of diseases, especially diseases in which the regression of inflammation is delayed or disrupted.

Description

technical field [0001] The present invention relates to the field of immunotherapy. The present invention provides a novel humanized anti-chemerin receptor antibody (humanrized anti-chemerin receptor) with resolvin E1 (Resolvin E1) agonist activity to chemokine like receptor-1 (chemokine like receptor-1, CMKLR1). receptor antibody). The present invention also provides the use of such antibodies in therapy, especially in the treatment of autoimmune and chronic inflammatory diseases, infectious diseases, cancer, and any condition in which the phase of resolution of inflammation is interrupted or delayed. Background technique [0002] The critical role of inflammatory processes in health and disease has long been recognized. The detailed molecular mechanisms and biological events that regulate the progression and resolution of inflammation remain of great interest. Recent studies provide strong evidence that the resolution of inflammation is not as passive a process as previ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P29/00A61P35/00C07K16/28
CPCA61P29/00A61P35/00C07K2317/24C07K2317/76C07K16/2866C07K2317/70A61K2039/505A61K2039/507C07K2317/75C07K16/2878C07K16/2818C07K2317/33C07K2317/73C07K16/2803C07K16/2839C07K16/241C07K2317/34C07K2317/92C07K2317/94A61P37/06
Inventor V·戈捷N·普瓦里耶C·马里C·特里约
Owner OSE IMMUNOTHERAPEUTICS