Porous skin-core structure phase-change temperature-regulating controlled-release fiber dressing and preparation method thereof

A skin-core structure and fiber technology, applied in the field of biomedicine, can solve the problems of not being able to achieve wound temperature regulation and drug release control at the same time, increase processing costs, and single function, and achieve good industrialization prospects, easy operation, and improve the effect of single function

Pending Publication Date: 2022-08-02
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation of drug-loaded fiber membranes or temperature-regulating fiber membranes as wound dressings has the disadvantage of single function, which cannot meet the requirements of wound temperature regulation and drug release control at the same time, and the operation is complicated, resulting in increased processing costs.

Method used

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  • Porous skin-core structure phase-change temperature-regulating controlled-release fiber dressing and preparation method thereof
  • Porous skin-core structure phase-change temperature-regulating controlled-release fiber dressing and preparation method thereof
  • Porous skin-core structure phase-change temperature-regulating controlled-release fiber dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1—The preparation of the skin layer spinning solution and the core layer spinning solution, and the preparation of the fiber dressing:

[0039] Preparation of cortex spinning solution:

[0040] Polylactic acid (PLA) (purchased from Natureworks, USA, specification model 6252D) was added to a mixed solvent of dichloromethane (DCM) and N,N-dimethylacetamide (DMF) (mass ratio DCM / DMF=19: 1), prepare a blended solution with a mass fraction of 12%, and mechanically stir for 6 hours at a rotating speed of 400 r / min to form a uniform cortex spinning solution. The solvent and the non-solvent are mixed according to a mass ratio of 19:1, and stirred evenly to obtain a cortex spinning solution.

[0041] Preparation of core layer spinning solution:

[0042] Weigh 60g of medicinal polyethylene glycol (PEG1000) and 10g of polyethylene glycol (PEG1500), put them into an oven after mixing, and treat at 50 ° C for a period of time until the mixed polyethylene glycol (PEG) is in...

Embodiment 2

[0046] Same as Example 1, the difference is that polylactic acid (PLA) is dissolved in a mixed solvent of dichloromethane (DCM) and N,N-dimethylacetamide (DMF), and the mass fraction is 10%.

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Abstract

The invention provides a porous skin-core structure phase-change temperature-regulating controlled-release fiber dressing and a preparation method thereof. The phase-change temperature-regulating controlled-release fiber dressing at least comprises a skin layer material and a core layer material, wherein the skin layer material is prepared by dissolving a high polymer material in a mixed solution; wherein the core layer material comprises an energy storage phase change material and a model drug, and the model drug is dissolved in the energy storage phase change material; wherein the initial temperature of the porous skin-core structure phase-change temperature-regulating controlled-release fiber dressing for realizing drug controlled release and wound temperature regulation is 33-37 DEG C, and the temperature regulation temperature is between 1 DEG C and 10 DEG C. The phase-change temperature-regulating controlled-release fiber dressing is prepared by a coaxial electrostatic spinning technology. The phase-change temperature-regulating controlled-release fiber dressing prepared by the invention has a phase-change temperature-regulating function, and can achieve the effects of drug controlled release and wound temperature regulation at the same time. And the preparation method of the phase-change temperature-regulating controlled-release fiber dressing is simple, convenient and efficient to operate, and can be used for large-scale production.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a porous skin-core structure phase-change temperature-regulating controlled-release fiber dressing and a preparation method thereof. Background technique [0002] With the continuous development of modern medicine, people's requirements for wound dressings are getting higher and higher, and traditional dressings are difficult to meet the needs. [0003] Wound healing is a dynamic and complex process. The local temperature of the wound fluctuates greatly when the dressing is changed. To reduce the adverse effects of hindering wound healing and to make the patient feel more comfortable, temperature control is very important. When the dressing is changed, the local temperature of the wound is too low, which will cause the patient's capillaries to constrict, resulting in local blood circulation disorders, the body's stress response, aggravating pain and delaying wound healing. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/44A61L15/26D01F8/14D01F8/16D01D5/34
CPCA61L15/425A61L15/42A61L15/44A61L15/26D01F8/14D01F8/16D01D5/34A61L2400/12A61L2300/602A61L2300/412C08L67/04C08L71/02Y02E60/14
Inventor 赵瑾朝何翠徐兆宝黄乐平
Owner WUHAN TEXTILE UNIV
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