Two-stage double-zymolyte integrated fermentation productive method for 1,3-propylene alcohol

Abstract

The invention discloses a two-stage double-substrate integrated fermentation production method of 1,3-propanediol, which belongs to the technical field of biosynthetic production methods of 1,3-propanediol. It is characterized in that the secondary seed cultivation of the present invention uses glucose and glycerol as a mixed double substrate, and the secondary seed cultivation under aerobic conditions and the anaerobic conversion of glycerol under anaerobic conditions are integrated in the same fermenter , and whether the glucose is exhausted is the condition for the transition from aerobic to anaerobic. The invention can reduce the process steps, improve the utilization rate of equipment, shorten the process cycle without affecting the final concentration of 1,3-propanediol, and avoid the chance of infection of miscellaneous bacteria caused by system conversion.

Description

Technical field: [0001] The two-stage dual-substrate integrated fermentation production method of 1,3-propanediol relates to the technical field of 1,3-propanediol production, in particular to the technical field of biosynthetic production methods of 1,3-propanediol. Background technique: [0002] 1,3-Propanediol (1,3-propanediol, 1,3-PD) is an important chemical raw material, in addition to being used as a solvent like other glycols, it is mainly used as a monomer for the synthesis of polyester and polyurethane , Polytrimethylene terephthalate (PTT) produced with 1,3-PD as a monomer is a new type of polyester material with easy dyeing, good elasticity, excellent softness, drapability, low static electricity, and Biodegradable and other advantages, mainly used in the production of fibers and textiles, such as carpets, socks, sportswear, etc. At present, the industry mainly adopts chemical synthesis and biosynthesis to produce 1,3-propanediol. The chemical synthesis has the ...

AI Technical Summary

Problems solved by technology

In the above steps, the secondary cultivation of seeds under aerobic conditions and the anaerobic conversion of glycerol in the next step are carried out in two systems respectively, so that the fermentation period is lengthened, the utilization rate of the equipment is reduced, and the operation steps are increased simultaneously, and in the In the process of transferring from one system to another, the chance of infection with miscellaneous bacteria is increased, which will adversely affect the subsequent process