Ginkgo leaf powder for injection and its preparation

Abstract

The invention relates to a ginkgo leaf extract powder injection, which contains 1 weight part of ginkgo leaf extract, 1-4 weight parts of hydroxypropyl beta cyclodextrin, and 0.02- 0.08 parts by weight. Its preparation method is: take ginkgo biloba extract, add hydroxypropyl beta cyclodextrin and mix in proportion, add acid-base regulator, filter, and the filtrate is ultrafiltered through a 50000-150000 Dalton ultrafiltration membrane, ultrafiltration The liquid is directly aseptically freeze-dried or aseptically spray-dried to form a powder for injection. On the basis of fully retaining the active ingredients, the preparation effectively removes impurities such as macromolecules, pyrogens, particles (including resin exfoliation), microorganisms, etc. in the original extract, and the safety and stability of the preparation are significantly improved.

Description

(technical field)

[0001] The invention relates to a ginkgo leaf extract powder injection and a preparation method of the ginkgo leaf extract powder injection, belonging to the field of traditional Chinese medicines. (Background technique)

[0002] Ginkgo biloba is the leaf of Ginkgo biloba L. Ginkgo biloba is a specialty plant in my country and one of the existing ancient relic plants. The extract of Ginkgo biloba has a certain effect on the treatment of coronary atherosclerotic heart disease, myocardial infarction, expansion of cerebral blood vessels, increase of cerebral blood flow, and treatment of ischemic encephalopathy. Modern medical research has proved that ginkgo leaves and other parts contain various active chemical components such as flavonoids and terpenoids, which have various physiological activities. According to reports, the main flavonoids quercetin, kaempferol and isorhamnetin in Ginkgo biloba have good effects on improving heart and brain blood circulati...