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Application of wolfberry polyose in the preparation process of gastric ulcer treating medicine

A technology of Lycium barbarum polysaccharide and gastric ulcer, which is applied in the field of application of Lycium barbarum polysaccharide in the preparation of drugs for treating gastric ulcer, and can solve the problems that the anti-gastric ulcer effect has not been reported.

Inactive Publication Date: 2006-05-31
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, many studies have reported that Lycium barbarum polysaccharide has various biological activities such as enhancing immunity, anti-cancer, anti-aging, increasing hematopoietic function, and preventing genetic damage, but the anti-gastric ulcer effect has not been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Example 1. Screening of active parts of Lycium barbarum polysaccharides for anti-gastric ulcer

[0011] (1) Anti-gastric ulcer effect and results of Lycium barbarum polysaccharide

[0012] Firstly, dialysis is used to divide Lycium barbarum polysaccharide into large molecular weight part and small molecular weight part, and the inhibitory effect on the absolute ethanol ulcer model in rats is used as an index to screen. Select 160-200g SD rats with body weight, half male and half male, and be divided into 6 groups at random: normal saline group (NS group), positive control group (sucralfate group, 250mg / kg), large molecular weight polysaccharide (greater than 8000 molecular weight) dose 1 Group (500mg / kg) and dose II group (250mg / kg), small molecular weight sugar (less than 8000 molecular weight) dose I group (500mg / kg) and dose II group (250mg / kg). The administration was continued for seven days, and the rats were fasted for 24 hours before the last administration. Dur...

Embodiment 2

[0026] Embodiment 2, the preparation of Lycium barbarum polysaccharide extract

[0027] Take the dried wolfberry fruit, add water to extract twice in total; combine the water extracts and concentrate; add 4 times the amount of 80% ethanol, let it stand overnight, take the precipitate and add water to dissolve it and then alcohol precipitation once; add a certain amount of water to dissolve the precipitate, and remove it by Sevag method Free protein; freeze-dried to obtain the crude polysaccharide of Lycium barbarum with a yield of about 5%. Put the total sugar of wolfberry into a dialysis bag for dialysis, and obtain macromolecular polysaccharides after the dialysis inner fluid is dried. Put the large molecular weight polysaccharide on an activated carbon column, elute with a gradient of 0.01-1mol / l NaCl, collect it with an automatic collector of 8ml per tube, detect it with a sulfuric acid-anthrone method, make an elution curve, combine the peak parts, concentrate and dry, an...

Embodiment 3

[0028] Example 3 Preparation of Lycium barbarum polysaccharide gastric floating tablet

[0029] Lycium barbarum polysaccharides LBP-2 and LBP-4 10 grams, HPMC, stearyl alcohol, magnesium stearate, 40 grams in total. Preparation: Mix the main ingredients and auxiliary materials evenly, pass through a 100-mesh sieve, add a binder to make a soft material, pass through a 16-mesh sieve to granulate, dry at 40°C, and granulate. Add magnesium stearate as a lubricant, mix and compress into tablets to make 100 tablets, each 0.5 g.

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PUM

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Abstract

The invention relates to the application of Lycium barbarum polysaccharide in the preparation of medicine for treating gastric ulcer. Lycium barbarum polysaccharide in the present invention refers to LBP-2 and LBP-4 separated from Lycium barbarum polysaccharide. Animal experiments have shown that LBP-2 has a significant inhibitory effect on mouse gastric ulcers caused by absolute ethanol and indomethacin, and LBP-4 has a significant inhibitory effect on mouse gastric ulcers caused by absolute ethanol. Inhibitory effect, can be used as a drug for the treatment of gastric ulcer.

Description

Technical field: [0001] The invention relates to the technical field of medicines, in particular to the application of Lycium barbarum polysaccharide in the preparation of medicines for treating gastric ulcer. Background technique: [0002] Lycium barbarum is the dry and mature fruit of Lyeium barbarum.L, a plant of the Solanaceae family. It has the functions of nourishing liver and kidney, benefiting energy and improving eyesight. The study found that wolfberry contains polysaccharides, protein, fat, V A , V B1 And amino acids, calcium, iron, germanium and other trace elements and minerals. Meng Xiezhong reported that there are 10 free amino acids in the fruit of Ningxia wolfberry, such as aspartic acid, glutamic acid, and alanine. Harsh MI reported that Lycium barbarum contains alkaloids such as belladonnaine and hyoscyamine. Wang Qiang et al. reported that polysaccharides from Lycium barbarum were extracted using organic solvents and hydroalcoholic methods. Chu Yanm...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P1/04
Inventor 冯怡徐德生张一芳
Owner SHANGHAI UNIV OF T C M
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