Cleaning production method of raw drug N-trimethyl lysine and application method

A technology of trimethyl lysine and a production method, which is applied in the clean production and application field of raw material drug-N-trimethyl lysine, can solve the problems of factory area and environmental pollution, difficulty in guaranteeing the quality of laminarin and the like , to achieve good quality, eliminate the danger of polluting the production workshop and the environment, and achieve the effect of cleaner production

Inactive Publication Date: 2007-05-23
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, in the existing technology, the Chinese patent application CN 97123269.5 discloses a preparation method of laminin, but toxic copper carbonate, dimethyl sulfate and hydrogen sulfide are used as raw materials in the synthesis process, which is not only difficult to ensure that it can be used as a medicine The quality of laminin, but also cause defects such as factory area and environmental pollution

Method used

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  • Cleaning production method of raw drug N-trimethyl lysine and application method
  • Cleaning production method of raw drug N-trimethyl lysine and application method

Examples

Experimental program
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Effect test

Embodiment 1

[0029] In a 500L reactor, first add 300 kg of distilled water, weigh 75 kg of food grade (feed grade) zinc sulfate and stir for 20 minutes to dissolve, then slowly add 91 kg of L-lysine hydrochloride into the reactor while stirring , 60 ℃ constant temperature reaction for 1 hour, let lysine and Zn 2+ The reaction is complete; then react with 135 kg of dimethyl carbonate to generate a complex of quaternized lysine derivatives, and then react with 79 kg of ethylenediaminetetraacetic acid disodium salt to obtain N-trimethyl Crude lysine, finally use strong acid cation resin exchange column to absorb N-trimethyllysine, wash with deionized water or ethanol, concentrate under negative pressure, and crystallize to obtain 110 kg of raw material drug N-trimethyllysine .

Embodiment 2

[0031] In a 100L reaction kettle, first add 55kg of distilled water, weigh 13kg of drinking water grade ferrous sulfate and stir for 20 minutes to dissolve, then slowly add 19kg of L-lysine hydrochloride into the reaction kettle under stirring, at 60°C Constant temperature reaction for 1 hour, let lysine and Fe 2+ Reaction is complete; Then react with 27 kilograms of dimethyl carbonates to generate the complex of quaternized lysine derivatives, and then react with 16 kilograms of ethylenediaminetetraacetic acid disodium salts to obtain the crude product of laminin. Finally, the strongly acidic cation resin exchange column was used to adsorb N-trimethyllysine, washed and purified with deionized water, desorbed with dilute ammonia water, concentrated in vacuum, and finished to obtain 21 kg of N-trimethyllysine as a raw material.

Embodiment 3

[0033] In a 200L reaction kettle, first add 100kg of distilled water, weigh 27kg of feed grade copper sulfate and stir for 20 minutes to dissolve, then slowly add 37kg of L-lysine hydrochloride into the reaction kettle under stirring, at a constant temperature of 60°C React for 1 hour, let lysine and Cu 2+ Reaction is complete; Then react with 54 kilograms of dimethyl carbonates to generate the complex of quaternized lysine derivatives, and then react with 31 kilograms of ethylenediaminetetraacetic acid disodium salts to obtain the crude product of laminin, Finally, the N-trimethyllysine was adsorbed on a strongly acidic cation resin exchange column, washed and purified with deionized water, desorbed with dilute ammonia water, vacuum concentrated, and crystallized to obtain 40 kg of N-trimethyllysine as a raw material drug.

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Abstract

The invention discloses a method for the clean production of N-trimethyllysine and method of application, wherein the production method consists of screening and protecting alpha-amino with metallic ions, carrying out epsilon-amino reaction between dimethyl carbonate, an environment-friendly type methylating reagent with lysine, obtaining quaternized lysine derivative (N-trimethyllysine metallic complex), finally de-screening the metallic ions with amino carboxyl chelating agent, then isolating and purifying with ion exchange process so as to obtain medicinal grade of N-trimethyllysine, which can be used as the raw material for medicament for preventing or treating high blood pressure, lowering blood fat, maintaining blood vessel, or as food, health product additives.

Description

Technical field: [0001] The invention relates to a clean production method of laminacin. In particular, non-toxic, environment-friendly chemical raw materials and modern ion exchange technology are used in the entire preparation process of N-trimethyllysine, which not only guarantees the production of N-trimethyllysine N-trimethyllysine is used as a quality requirement for medicine or food additives, and at the same time it truly ensures that N-trimethyllysine is a green product. N-trimethyllysine can be used not only as a raw material for preventing cardiovascular and cerebrovascular diseases, but also as an additive for food and health products. Background technique: [0002] Kelp is a well-known edible algae that is rich in nutrients. Kelp contains a non-protein amino acid with special physiological effects, that is, N-trimethyllysine. Because kelp is another name for kelp, N-trimethyllysine is also called laminin. N-trimethyllysine has a special effect of lowering bloo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C229/26C07C227/18
Inventor 李群李子超李艳春
Owner QINGDAO UNIV
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