Prepn and application of individual antitumor specific antibody

A specific, anti-tumor technology, applied in anti-tumor drugs, antibodies, anti-animal/human immunoglobulins, etc., can solve the problem of difficulty in preparing anti-tumor specific antibodies

Inactive Publication Date: 2002-04-17
刘文泰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The second is that tumor-specific antigens or tumor-associated antigens with weak immunogenicity are easily covered by other antigens with strong immunogenicity

Method used

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Examples

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specific Embodiment approach 1

[0021] Specific embodiment one: use Syrian hamsters to prepare compound preparations containing anti-tumor specific antibodies Example 1. There are the following six methods for inducing Syrian hamsters to the immune tolerance of patient tumor primary organ cells: (1), giving newborns 24 hours Intraperitoneal injection of leukocytes from tumor patients in Syrian hamsters 1-8×10 6 , to induce immune tolerance in animals to the normal cells of the patient. (2), intraperitoneal injection of 1 to 8×10 Syrian hamsters within 24 hours of newborns 6 The normal cells of the primary organ of the patient's tumor induce the immune tolerance of the animal to the normal cells of the primary organ of the patient's tumor. (3) Intraperitoneal injection of 1 to 4×10 Syrian hamsters within 24 hours of newborns 6 Normal human tumor primary organ normal cells and 1~6×10 6 Leukocytes from patients with tumors can induce animal immune tolerance to normal cells in the primary organ of the patient...

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Abstract

The present invention proposes the preparation of one kind of individual antitumor specific antibodys and its application in medicine preparation for tumor guide treatment and positioning diagnosis. The antibody preparing process includes three steps of inducing animal's immune tolerance, immunizing animal and extracting antibody. It is featured by that the health tissue cell of tumor patient is first used to induce animal's immune tolerance, and after the animal immune function becomes mature, the tumor cell of tumor patient is then used to immunize animal so as to prepare antitumor specific antibody.

Description

technical field [0001] The invention relates to a preparation method and application of an individualized anti-tumor specific antibody, belonging to the technical field of biopharmaceuticals or preparations. Background technique [0002] The preparation of anti-tumor specific antibodies is a crucial link in tumor-directed therapy and localized diagnosis. However, it is very difficult to prepare anti-tumor-specific antibodies against different tumors, which seriously hinders the progress of tumor-directed therapy and targeted diagnosis. There are two main reasons: the first is that in addition to the same tumor-specific antigens among different patient tumors induced by the same virus, even the same type of tumors have different tumor-specific antigens or tumor-associated antigens among different patients. Therefore, it is impossible to produce anti-tumor specific antibodies that can specifically bind to all tumors or tumors of the same type. The second is that tumor-specif...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61P35/00C07K16/18
Inventor 刘文泰李丽华
Owner 刘文泰
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