Process for screening active components playing weight losing and hypolipemic role from Chinese-herbal medicines

Abstract

A process for screening the active weight losing-hypolipemic component from Chinese-medicinal materials features that one or more of fatty acid synthetase, acyl-CoA synthetase and the differentiationof mouse and human pre-fat cells to mature fat cells are combined as target of said screening. Its advantages are clear target, and large-scale screening.

Description

Technical field: [0001] The invention belongs to the field of biotechnology, and in particular relates to a method for screening active ingredients in Chinese herbal medicines for weight loss and fat reduction at molecular level and cell level. Background technique: [0002] Obesity is a worldwide medical problem. A large amount of evidence has shown that obesity is closely related to various diseases, such as hypertension, hyperlipidemia, diabetes, cardiovascular and cerebrovascular diseases, breast cancer, female infertility, and mental retardation in children. Taking BMI (Body Mass Index) males greater than 27.8 and females greater than 27.3 as the obesity standard, the total number of obese people aged 18-74 in my country is about 70 million, accounting for 5.8% of the total population; the total number of obese people in the same age population in the United States is about 6800 million, accounting for 20% of the total population. my country's annual consumption for we...

AI Technical Summary

Problems solved by technology

The side effects of the two are very obvious, sibutramine causes dry mouth, palpitations, and fatigue, and orlistat causes oily stools and fat-soluble vitamin deficiency

Western countries have also been developing weight-loss drugs based on new principles. For example, it was found that xanthine derivatives can increase energy expenditure by accelerating oxidative metabolism in the body. A large number of clinical trials have proved that caffeine and ephedrine alone The use or combined use has a certain weight loss effect, but it has not been clinically approved because of its side effects that can cause tachycardia and palpitations; in the mid-1990s, the mouse ob gene expression product leptin (leptin) was discovered and cloned , and proved that it has a certain weight loss effect on genetically obese rats, but genetically obese individuals only account for 5-10% of the total number of obese individuals, and this substance causes severe local redness, swelling and pain when injected, so it has also been used so far. Not clinically licensed

To sum up, the main disadvantages of existing weight-loss drugs are large side effects and low clinical efficacy, both of which are related to the unscientific design of drug targets

However, due to limitations such as unclear active ingredients and pharmacological mechanisms of Chinese herbal medicines, traditional Chinese herbal medicines cannot go to the world, so there is no weight-loss drug with independent intellectual property rights in my country so far.

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