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Intradermal injection system for injecting DNA-based injectables into humans

A technology for injections and syringes, applied in the field of ID injections, can solve problems such as inability to effectively deliver ID injections

Inactive Publication Date: 2003-02-26
BIOJECT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Needle-free injection systems (other than those described here) also have drawbacks in that they cannot effectively deliver DNA-based ID injections (described in detail later in this article)

Method used

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  • Intradermal injection system for injecting DNA-based injectables into humans
  • Intradermal injection system for injecting DNA-based injectables into humans
  • Intradermal injection system for injecting DNA-based injectables into humans

Examples

Experimental program
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Effect test

Embodiment Construction

[0017] The needle-free injection system described herein can effectively administer ID injections in the same volume range as needle and ampoule system injections, without special technique or training. To increase the efficiency of ID injections, an ID base was developed to attach to the distal end of the ampoule of a preferred embodiment of the present invention, as disclosed herein in both U.S. Patent No. 5,399,163 and pending U.S. Patent Application No. 08 / 858,249. Needle-free injection systems are fully incorporated by reference. For both systems, the actual injection site on the body can be many different places (eg, the middle of the forearm or around the knee).

[0018] In a preferred embodiment of the present invention, the intradermal base shown in Figure 12 is used in conjunction with the needle-free injection system described in U.S. Patent No. 5,399,163 or pending U.S. Patent Application No. The ampoule portion is shown in 10. The cross section of the intraderma...

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PUM

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Abstract

A system for injecting DNA-based medications into humans is provided by the present invention. The system includes a needle-free injector (10) with an injection orifice of approximately 0.004 inches for supplying DNA-based medication at an initial pressure of from 3900 to 4300 psi, and then immediately declining to a level of about 2800 to 3800 psi, and then immediately cutting off pressure to terminate the injection. The injector includes an annular adapter (12) for spacing the injection orifice from the skin of the patient. The adapter includes an abutment (16) against which the injector is disposed so that the orifice is spaced approximately 0.76-1.0 inch from the skin of the patient, the adapter having an inner diameter at the distal end of approximately 0.50-0.70 inches.

Description

Background of the invention [0001] Systems for delivering injections into the body have been used for many years. The most common is a hypodermic needle used with ampoules. To inject, the needle is inserted into the tissue to the desired depth, and the operator simply pushes the plunger inside the ampoule to deliver the injectate. Other less used methods are needle-free injection systems. These systems generally consist of a device and an ampoule. The device generates power and contains an injection in an ampoule. Ampoules generally have an annular opening at their distal end about 1 / 100 the size of their inner diameter. The device pushes liquid through this opening at high velocity (enough to penetrate tissue and deliver an injectable). To inject, the operator typically holds the tip of the ampoule against the patient's skin and triggers the trigger. With needle-free injection systems, the depth of injection is controlled by the device rather than the operator. [0002...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/30C12M3/00
CPCA61M5/30
Inventor R·R·斯托特R·A·米勒J·M·博尼卡托
Owner BIOJECT
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