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Injection of sodium bouttuynin, and its prepn. method

A new technology for sodium houttuyniacin and injection, applied in the field of medicine, can solve problems such as toxic side effects, easy to produce hemolysis, etc., and achieve the effects of stable injection and safe application

Inactive Publication Date: 2004-07-21
王景成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to increase the concentration of the liquid medicine, Tween-80, a cosolvent, is added to the prescription, which is not only prone to hemolysis, but also has certain toxic and side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Example 1: Weigh 15g of hydroxypropyl-β-cyclodextrin, put it in 150ml of water for injection, stir and dissolve, take another 1g of neohouttuyfonate sodium, add it to the above-mentioned hydroxypropyl-β-cyclodextrin solution, After stirring for 30 minutes, add 7.5g of mannitol, stir to dissolve, add water for injection to 250ml, mix well, filter with a 0.22um filter membrane, and divide the obtained solution into vials, each 1ml, freeze-dried, the new fish Houttuycin Sodium Freeze-dried Powder for Injection (4 mg per tube).

Embodiment 2

[0008] Example 2: Weigh 30g of hydroxypropyl-β-cyclodextrin, put it in 150ml of water for injection, stir and dissolve, take another 1g of neohouttuyfonate sodium, add it to the above-mentioned hydroxypropyl-β-cyclodextrin solution, After stirring for 30 minutes, add 8g of lactose, stir to dissolve, add water for injection to 250ml, mix well, filter with a 0.22um filter membrane, and divide the obtained solution into vials, each 5ml, freeze-dried, new Houttuynia cordata Sodium lyophilized powder for injection (20mg each).

Embodiment 3

[0009] Example 3: Weigh 50g of hydroxypropyl-β-cyclodextrin, put it in 250ml of water for injection, stir and dissolve, and take another 3g of neohouttuyfonate sodium, add it to the above-mentioned hydroxypropyl-β-cyclodextrin solution, After stirring for 30 minutes, add 10g of low-molecular-weight dextran, heat and stir to dissolve, add water for injection to 300ml, mix well, filter with a 0.22um filter membrane, divide the obtained solution into vials, 1ml each, freeze-dry, The new houttuyfonate sodium freeze-dried powder injection (each 10mg).

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PUM

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Abstract

A sodium neohouttuyfonate injection is prepared through dissolving hydroxypropyl-beta-dextrin in the water for injection, adding sodium neohouttuyfonate, stirring or grinding, and preparing injection liquid or (vacuum or freeze or spray) drying to obtain powdered injection.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular it is a new houttuyfonate sodium injection and a preparation method. Background technique: [0002] Sodium New Houttuyfonate (Sodium New Houttuyfonate), the chemical name is lauryl acetaldehyde sodium bisulfite and the active ingredient Houttuyfonate in natural houttuyfonate is the same series of sodium bisulfite addition thing. The pharmacological effects and curative effects of the two are basically similar, both are antibacterial and anti-inflammatory drugs, and they have certain inhibitory effects on influenza bacillus, Staphylococcus aureus, Haemophilus influenzae, and Candida albicans. It can also increase the level of serum properdin and enhance the phagocytic ability of white blood cells, thereby improving the body's non-specific immunity. It is clinically used for pneumonia, chronic bronchitis, respiratory tract infection, etc. It is also used for gynecological inflamma...

Claims

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Application Information

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IPC IPC(8): A61K31/255A61P11/00A61P15/00A61P29/00
Inventor 王景成王文彬
Owner 王景成
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