Process for preparing buccal lozenge contg. compound sede-iodine

A technology of cedi iodine and buccal tablets, applied in the direction of iodine compound active ingredients, digestive system, pill delivery, etc., can solve the problems of harmfulness and non-benefit, and achieve the effect of being willing to accept, good curative effect and enhancing stability

Inactive Publication Date: 2004-07-21
陈文政
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a drug for human use, KI has medicinal effects, and the use and presence of KI in the drug is not always beneficial to the human body; as the main active ingredient I 2 , while playing a therapeutic role, I 2 molecule becomes iodide ion (I - ); the use of KI, especially in the use of cediodine tablets as OTC class B drugs, the human body will absorb more potassium ions (K + ) and iodide ion (I - ), therefore, the use of more KI in cediiodine tablets may be harmful to the human body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Preparation of Cediiodine

[0025] 1. Take 10.0g of iodine and dissolve it in 95% ethanol or absolute ethanol to prepare iodine tincture.

[0026] 2. Take 100g of β-cyclodextrin, add 300ml of 20% ethanol, and heat to 65°C to dissolve to make β-cyclodextrin solution.

[0027]3. Drop the iodine solution into the β-cyclodextrin solution, stir and react at 65-70°C for 2hrs, after it is cooled to room temperature, place in the refrigerator overnight, filter with suction, wash with water and dilute ethanol in turn, and drain the coffee-colored solid at 60°C. Dry at -70°C, pass through a 120-mesh sieve, weigh, and measure the content for later use. The weight yield is 95.0-97.0%, and the iodine yield is 90.0-95.0%.

Embodiment 2

[0028] Example 2 Preparation of compound cidiiodine buccal tablets

[0029] 1. Material handling: Pass the sucrose through an 80-mesh sieve, and pass the raw materials of sodium carboxymethyl cellulose, hypromellose and cediiodine through a 120-mesh sieve.

[0030] 2. Take 2.1 g of menthol and 4.3 g of citric acid, add an appropriate amount of 95% ethanol, stir and dissolve to make a solution ①.

[0031] 3. Take 19.0g of cediiodine, 435g of sucrose, 4.5g of sodium carboxymethyl cellulose (or 4.5g of hypromellose, or both, or neither), using a high-speed material mixer, Mix well, add appropriate amount of water to make soft material①, then add solution ① evenly to make moist soft material②. The soft material ② is granulated through a 20-mesh sieve, dried at 60-70°C, added with 4.5g of magnesium stearate, mixed uniformly, granulated, measured for particle content, and compressed to obtain compound cidiiodine buccal tablets. Specification 1.5mg; tablet weight 0.45-0.48g; tablet thick...

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PUM

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Abstract

A buccal lozenge of compound cydiodine for treating oral and throat diseases is prepared from iodine, beta-dextrin, cane sugar, citric acid and menthol. Its advantages are broad spectrum, high bactericiding power, high stability, and agreeable taste.

Description

Technical field [0001] The invention relates to a preparation method of a compound cediiodine buccal tablet, which is currently an excellent medicine for the treatment of oral and throat diseases in clinical practice. Background technique [0002] Oral diseases (oral ulcers, stomatitis, gingivitis, periodontitis, pericoronitis, etc.), throat diseases (acute and chronic pharyngitis, tonsillitis, etc.) are common and frequently-occurring diseases in the department of stomatology and otolaryngology. Iodine (I 2 ) Has been used as a disinfectant for more than 100 years. It has a non-selective killing effect on bacteria, fungi and viruses, and can be called a broad-spectrum high-efficiency disinfectant. However, due to the poor stability of the physical and chemical properties of iodine itself, its strong odor and irritation to the skin, oral cavity, and throat mucosa, it limits the clinical application of iodine. In the past, the most common dosage form used in clinical practice was ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K33/18A61P1/02A61P11/04
Inventor 陈文政
Owner 陈文政
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