Hypericum japonicum total flavone powder injection and preparing method thereof

A technology of total flavonoid powder injection and Tianjihuang, which is applied in powder transportation, antiviral agents, pharmaceutical formulations, etc., can solve the problems of inconvenient use and easy freezing, and achieve the effects of convenient transportation, long storage period and stable quality

Inactive Publication Date: 2004-09-15
张晴龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, Tianjihuang injection is a water injection, which is fragile in terms of transportation and storage, and it is easy to freeze in northern my country and cold regions, which brings inconvenience to use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Refer to [WS-10078(ZD-0078)-2002] method to prepare field base total flavonoid concentrate, add ascorbic acid or cysteine ​​and low molecular dextran or glucose or chloride to the above concentrate in the workshop below 100 grades One or two kinds of sodium, the total amount of pharmaceutical excipients is 10% of the total flavonoids in the solution, fully dissolved at 40-80°C, and the pH is adjusted to 6.5-7.0, and the solution is sterile ultrafiltered to obtain clarity Medicinal solution, spray-dried, airtight for 24 hours, cooled to obtain the required powder injection raw materials, aseptically divided into 5ml vials, 0.3mg / bottle (calculated as total flavonoids of Tianjihuang), capped, after passing the inspection, Packaging is the finished product.

Embodiment 2

[0066] With reference to [WS-10078 (ZD-0078)-2002] method, prepare Tianji total flavonoid concentrate, in the workshop below 100 grades, add metered water-soluble pharmaceutical excipients for injection to the concentrate, wherein cysteine ​​or The glutathione content accounts for 20% of the amount of excipients. Under the condition of 40-80°C, it is fully dissolved, and the pH is adjusted to 6.5-7.5. The solution is sterile ultrafiltered, and water for injection is added to adjust the total flavonoid concentration of Tianjihuang in the solution to 0.6 mg / ml, aseptically filled in 3ml ampoules, 0.5ml each, freeze-dried, each ampule contains ≥0.3mg of total flavonoids of Tianjihuang (calculated as quercetin), melted and sealed, and passed the inspection Finally, the finished product is packaged.

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PUM

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Abstract

The present invention relates to a medicine with special dosage form of curing viral hepatitis and its preparation method. It is characterized by that the described grangae maderaspatana total flavone powder injection is formed from grangea maderaspatana total flavone and injection water-soluble medicinal auxiliary material, the grangea maderaspatana total flavone content is 50-99.5 wt%, the rest is medicinal auxiliary or water content. Said powder injection includes spray-dried powder injection and freeze-dried powder injection. Said invention has the functions of clearing away heat and promoting diuresis, dissipating blood stasis and promoting the subsidence of swelling, so that it is suitable for curing viral hepatitis.

Description

[0001] The technical field of the invention [0002] The invention relates to a pharmaceutical preparation in powder injection form with total flavonoids of Tianjihuang as the main active ingredient and a preparation method thereof. Background technique [0003] Viral hepatitis is one of common disease, frequently-occurring disease at present. The total flavonoids of Tianjihuang has a good therapeutic effect on viral hepatitis. There are 23 Chinese patents using Tianjihuang as a compatible ingredient, and all of them are compound preparations. Among them, the Chinese patent CN1322558 is an anti-liver cancer drug, and the dosage form is oral liquid. It is composed of 34 traditional Chinese medicines; Chinese patent CN1368379 is a Paishi powder for treating gallbladder stones, the dosage form is a powder, and it is composed of more than 34 traditional Chinese medicines; As a functional drink, it is composed of 58 traditional Chinese medicines. There is only one Chinese patent ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/19A61K31/352A61P1/16A61P31/12
Inventor 张晴龙
Owner 张晴龙
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