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Complex external medicine mainly for acne

A technology of external medicines and compound prescriptions, which is applied in the direction of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve the problems of fluctuations in curative effect, single effect, and unstable quality, and achieve comprehensive therapeutic effects and satisfactory curative effects.

Inactive Publication Date: 2004-09-15
CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main problem with unilateral therapy is that it has a single effect and can only target 1 or 2 disease links at most (such as antibacterial plus anti-inflammatory, or antibacterial plus anti-angular suppository).
In addition, most of the above-mentioned acne keratolytic drugs have local irritation and / or allergic effects, and benzoyl peroxide has a strong oxidative effect. If they are composed of compound preparations, the quality is not easy to stabilize, which will cause fluctuations in the concentration and curative effect of compatible drugs. Storage conditions, shelf life and use Convenience and other aspects are greatly affected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The effective active ingredient of the present embodiment adopts adapalene 0.1% (percentage by weight, the same below) and clindamycin hydrochloride (or phosphoric acid) 1%, and the matrix carrier adopts cetyl alcohol, petrolatum, liquid paraffin, glycerol monostearate Esters, Glycerin, Solubilizers, Emulsifiers, Ethylparaben, and Distilled Water.

Embodiment 2

[0018] The effective active ingredients of this embodiment adopt 0.05% of adapalene and 2% of erythromycin, and the base carrier adopts cetyl alcohol, petrolatum, liquid paraffin, glyceryl monostearate, glycerin, solubilizer, emulsifier, ethyl hydroxybenzoate esters and distilled water.

Embodiment 3

[0020] First, two kinds of effective active ingredients in Example 1 or Example 2 and a total amount of 0.1% ethylparaben are dissolved in a solubilizer; then a total amount of 8-12% cetyl alcohol, a total amount of 5-10 % Vaseline, 8-12% of the total amount of liquid paraffin, 5-10% of the total amount of glyceryl monostearate and an appropriate amount of emulsifier are mixed and heated to 80-85°C; Mix an appropriate amount of distilled water and heat it to 80-85°C, and mix and emulsify it with the mixture of cetyl alcohol, vaseline, liquid paraffin, glyceryl monostearate and emulsifier; remove the emulsified mixture from the heat source, stir and cool to At 65°C, add a solubilizer containing two effective active ingredients and ethylparaben, and stir evenly to form a cream.

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PUM

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Abstract

The present invention relates to a compound medicine for external application mainly for curing acne. Its composition contains the following active components: (wt%) 0.01-2% of adapalin and 0.25-5% of antimicrobial. Said invented compound medicine has the following therapeutic actions: dissolving keratotic plug, regulating keratosis, resisting microbe, relieving inflammation and reducing secondary factor of sebaceous secretion, so that it can obtain good therapeutic effect.

Description

Technical field: [0001] The invention relates to a medicine for external use for treating acne, in particular to a compound medicine for external use mainly for treating acne. Background technique: [0002] Acne is a chronic disease of the sebaceous glands. It can be divided into inflammatory and non-inflammatory acne. It is the second most common disease in dermatology. The incidence rate accounts for about 7-10% of skin diseases. The age of the disease covers 11-30 years old, men and women Anyone can suffer. [0003] It is now known that the following four pathogenic factors and links play a key role in the occurrence, development and outcome of acne: 1. The microbial action in the hair follicle and sebaceous unit, first is the anaerobic Propionibacterium acnes, and the second is the aerobic bacteria Predominant pyogenic bacteria such as epidermis and Staphylococcus aureus, it is believed that Saccharomyces is also involved in the pathogenesis; 2, androgen and sebaceous g...

Claims

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Application Information

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IPC IPC(8): A61K31/4436A61K31/496A61K31/5383A61K31/65A61K31/7048A61P17/10
Inventor 郑家润张崇璞李新宇陈沄高纪伟唐美育徐兰芳
Owner CHUGOKU IGAKU KAGAKUIN HIFUBIYOU KENKYUSHO
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