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Benproperine phosphate dripping pills and preparation

A technology of benproperine phosphate and dropping pills, which is applied in the fields of pill delivery, active ingredients of phosphorus compounds, respiratory diseases, etc., and can solve the problem of affecting the therapeutic effect of benproperine phosphate, low dissolution rate and dissolution rate, and the proportion of excipients It is easy to carry and take, the dissolution rate and dissolution rate are improved, and the amount of excipients is reduced.

Inactive Publication Date: 2004-11-10
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Phenproperine phosphate has a special odor, bitter taste, and is easily soluble in water. However, the disintegration time of the tablet is long, the dissolution rate and dissolution rate are low, the absorption is poor, the bioavailability is low, and the proportion of excipients is large. Children, the elderly People, bedridden patients and patients with dysphagia are inconvenient to take and have poor compliance, which affects the therapeutic effect of benproperine phosphate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0050] prescription:

[0051] Phenproperine Phosphate 5g

[0052] Macrogol 6000 15g

[0053] Makes 1000 capsules

[0054] Preparation method: Take the fine powder of benproperine phosphate that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as coolant, make pellets by drop method, dry, Instantly.

example 2

[0056] prescription:

[0057] Phenproperine Phosphate 5g

[0058] Macrogol 4000 15g

[0059] Makes 1000 capsules

[0060] Preparation method: Take the fine powder of benproperine phosphate that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry. Instantly.

example 3

[0062] prescription:

[0063] Phenproperine Phosphate 5g

[0064] Macrogol 6000 5g

[0065] Macrogol 4000 10g

[0066] Makes 1000 capsules

[0067] Preparation method: Take the fine powder of benproperine phosphate that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten mixed matrix of polyethylene glycol 4000 and polyethylene glycol 6000, stir well, use simethicone oil as the coolant, Drop system into legal pills, dry, and get it.

[0068] 4. Example 4

[0069] prescription:

[0070] Phenproperine Phosphate 5g

[0071] Glyceryl monostearate 15g

[0072] Makes 1000 capsules

[0073] Preparation method: Take the fine powder of benproperine phosphate that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as the coolant, make pellets by dropping, dry, and have to.

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PUM

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Abstract

The invention discloses a Benproperine Phosphae drop pill prepared through ultramicro disintegration and drop pills manufacturing technique, which has the advantages of improving collapse, dissolving speed, and dissolving rate, quick effect, increased medicament stability, reduced adjuvant consumption, lowered production costs, easiness in application, and good compliance.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to benproperine phosphate dropping pills and a preparation method thereof. Background technique [0002] Phenproperine phosphate is a non-addictive antitussive drug, which can inhibit the cough center, can also inhibit the pulmonary-vagal reflex caused by stretch receptors in the lung and pleura, and can relax bronchial smooth muscle. That is, it has both central and peripheral dual antitussive action mechanisms. Phenproperine phosphate is easily absorbed when taken orally, and takes effect 10 to 20 minutes after taking the medicine, and the antitussive effect can last for 4 to 7 hours. It is clinically used to treat acute and chronic bronchitis and cough caused by various stimuli. [0003] Phenproperine phosphate has a special smell, bitter taste, and is easily soluble in water, but its tablet disintegration time is long, the dissolution rate and di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/66A61P11/14
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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