Compound formula preparation eontaining glucocorticoid medicine

A technology of glucocorticoids and corticosteroids, applied in the field of compound preparations, can solve problems such as lack of glucocorticoids, achieve the effect of convenient administration and elimination of iatrogenic adrenal hyperfunction

Active Publication Date: 2004-12-22
YOUCARE PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there is no report on the combination of glucocorticoids and Anemarrhena anemarrhena as a drug for glucocorticoid indications

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Prednisone+Anemarrhena extract is prepared into a compound preparation.

[0022] The extraction method of Anemarrhena is to use ethanol-water mixture (volume percentage of ethanol 60-80%), and soak the mixture for 3 times. Recover the ethanol under reduced pressure until it becomes a thick paste, combine the thick paste three times, add water to stir to dissolve, refrigerate, and discard the precipitate; the supernatant is concentrated to dryness under reduced pressure, let cool, and then add a small amount of methanol or ethanol to dissolve , add acetone to precipitate a white precipitate, wash the precipitate with acetone, and dry under reduced pressure to obtain the mother extract. That is to say, the Anemarrhena extract is a substance dissolved in ethanol and water mixed with an extraction solvent and precipitated in acetone, and this type of substance is mainly composed of anemarrhena total saponins. The extraction rate is about 2-3%.

[0023] Take by weighing 50...

Embodiment 2

[0025] Prednisone + Anemarrhena extract made into compound granules.

[0026] The extraction method of Anemarrhena extract is the same as in Example 1, and the volume-to-powder ratio of ethanol-water mixture ethanol should be 40-50%.

[0027] Weigh 200 grams of the above Anemarrhena extract, and another 10 grams of prednisone, add excipients, such as dextrin, starch, powdered sugar, mix well, add 80% ethanol to wet soft material, and sieve for 20 days Granulate, dry at 70°C to a moisture content of 4%±, pack into 2000 bags, and make granules.

Embodiment 3

[0029] Prednisone + Anemarrhena extract made into oral solution.

[0030] The extraction method of Anemarrhena extract is the same as that in Example 1, except that the volume-to-powder ratio of ethanol-water mixture ethanol is changed to 30-40%.

[0031] Weigh 100 grams of the above Anemarrhena extract, and weigh 1000 grams of prednisone, add a small amount of sucrose to taste, and add water to 200,000 ml, pack into 100 ml or 10 ml each, fill and seal, and prepare oral liquid.

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PUM

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Abstract

An orally applied medicine is prepared from glucocorticoid medicine and the extract of anemarrhena rhizome. It can eliminate the untoward reaction caused by glucocorticoid.

Description

technical field [0001] The invention relates to a compound preparation containing glucocorticoid drugs. Background technique [0002] Glucocorticoids (Glucocorticoids) mainly have anti-inflammatory and immune-suppressing effects, and are widely used clinically, such as in the treatment of nephrotic syndrome. However, long-term use of glucocorticoids in large quantities can cause many adverse reactions, such as iatrogenic adrenal hyperfunction, manifested as muscle weakness, full moon face, buffalo back, elevated blood sugar and blood lipids, etc., because glucocorticoids can reduce The defense ability of the body, and has no antibacterial effect, so it can induce infection or spread potential lesions in the body, such as viruses, molds, Mycobacterium tuberculosis, etc. At the same time, long-term use of glucocorticoids can also lead to accelerated protein decomposition in the body, negative nitrogen balance, and bone formation. Production decreases, causing osteoporosis. ...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61P13/12A61P29/00A61P37/06
Inventor 于圣臣韩丽萍李俭洪
Owner YOUCARE PHARMA GROUP
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