Method for the treatment of inflammation

A technology of inflammation and anti-inflammatory drugs, applied in the fields of immunology and pharmacology, can solve problems such as hypertension and nephrotoxicity

Inactive Publication Date: 2005-01-05
PROMETIC BIOSCIENCES LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Immunosuppressants may cause hypertension and nephrotoxicity

Method used

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  • Method for the treatment of inflammation
  • Method for the treatment of inflammation
  • Method for the treatment of inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of Dimethicone Oil

[0039] An oil composition containing dimethylsiloxane was prepared using the formulation described in Table 1 as follows.

[0040] Table 1

[0041] Dimethicone Composition Ingredients

[0042] Composition % weight

[0043] Dimethicone 10.0

[0044] Heavy mineral oil (Ramol 350) 79.4

[0045] Isopropyl myristate (emulsifier) ​​10.0

[0046] Lanolin alcohol (Amerchol L-101) 0.5

[0047] Sorbic acid 0.1

[0048] Total 100.0

[0049] Isopropyl myristate (INOLEX CHEMICAL CO) was heated to 54-60°C in a stainless steel vessel. Add sorbic acid (PENTA MANUFACTURING COMPANY) and mix until completely dissolved. Add AMERCHOL L-101 (CHARLES TENNANT COMPANY CANADAL TD) and mix, adjust temperature to 50-55°C and continue mixing until formulation is uniform. Dimethicone (SILICONE SF 96-350, GENERAL ELECTRIC COMPANY) and heavy mineral oil (CANADA COLORS AND CHEMICALS) were added ...

Embodiment 2

[0051] Preparation of Dimethicone Cream

[0052] A cream composition containing dimethicone was prepared using the formulation described in Table 2 as follows.

[0053] Table 2

[0054] Dimethicone Composition Ingredients

[0055] Composition % weight

[0056] Dimethicone 5.00

[0057] Glycerin 8.00

[0058] Anhydrous citric acid 0.06

[0059] Edetate Disodium 0.05

[0060] Atmul 84 4.00

[0061] Lanolin oil (Amerchol L-101) 3.00

[0062] Cholesterol 0.10

[0063] Emulgade 1000 8.00

[0064] Eumulgin B1 0.50

[0065] Purified water 71.29

[0066] Total 100.00

[0067] Oil Phase (Phase A):

[0068] Mix Atmul 84 (VAN WATERS & ROGERS), Amerchol L-101, Cholesterol (CRODA CANADA LTD, Canada), Emulgade 1000 (HENKEL), Eumulgin B1 (HENKEL), Dimethicone in a heating pot at 72-78°C alkanes (Silicone SF96-350, GENERAL ELECTRIC COMPANY, Canada).

[0069] Aqueous Phase (Phase B):

[0070] Purified water and g...

Embodiment 3

[0072] Preparation of Dimethicone Cream Containing Caprylic / Capric Triglycerides

[0073] A dimethicone cream composition containing caprylic / capric triglyceride was prepared as follows using the formulation described in Table 3 below.

[0074] table 3

[0075] Dimethicone Composition Ingredients

[0076] Composition % weight

[0077] Dimethicone 5.00

[0078] Caprylic / Capric Triglyceride 5.00

[0079] Glycerin 8.00

[0080] Citric acid (anhydrous) 0.06

[0081] Edetate disodium 0.05

[0082] Atmul 84 4.00

[0083] Lanolin oil (Amerchol L-101) 3.00

[0084] Cholesterol 0.10

[0085] Emulgade 1000 8.00

[0086] Eumulgin B1 0.50

[0087] Purified water 66.29

[0088] Total 100.00

[0089] Oil Phase (Phase A):

[0090] Atmul 84, Amerchol L-101, Cholesterol, Emulgade 1000, Eumulgin Bl, Caprylic / Capric Triglyceride (Croda Canada Ltd, Canada) and Dimethicone were mixed in a heating jug at 72-78°C.

[0091] Aqueous Phase (...

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PUM

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Abstract

A method for treating, eliminating and preventing an inflammation of the skin or mucous membrane of a mammal, including a human, by administering to the skin or mucous membrane a composition containing dimethicone and a pharmaceutically acceptable carrier. The dimethicone composition is applied to the skin or mucous membrane in an amount effective to treat, eliminate or prevent the inflammation.

Description

field of invention [0001] The present invention relates to the fields of immunology and pharmacology, and more specifically relates to a method for treating inflammation. Background of the invention [0002] Inflammation is a local response to cellular damage that results in the elimination of noxious mediators and tissue damage. Inflammation is a complete sequence of physiological and immunological events characterized by telangiectasia, leukocyte infiltration, redness, heat, pain and swelling. Polymorphonuclear neutrophils (hereinafter "PMNs") and eosinophils are important mediators of inflammation and release growth factors, cytokines, prostaglandins, leukotrienes and proteases that exacerbate tissue damage to the list. PMN-derived serine proteases such as elastase and cathepsin G are known causative agents of inflammatory and degenerative diseases involving abnormal tissue catabolism. [0003] Although inflammatory responses can be modulated by anti-inflammatory drugs ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/47A61K31/573A61K31/695A61K45/00A61K31/728A61K31/80A61K45/06A61P1/02A61P1/04A61P13/00A61P13/10A61P17/00A61P17/02A61P17/04A61P17/06A61P17/08A61P17/10A61P27/02A61P27/16A61P29/00A61P31/04A61P31/10A61P31/12A61P37/08A61P43/00
CPCA61K31/47A61K45/06A61K31/695A61K31/80A61K31/573A61P1/02A61P1/04A61P13/00A61P13/10A61P17/00A61P17/02A61P17/04A61P17/06A61P17/08A61P17/10A61P27/02A61P27/16A61P29/00A61P31/04A61P31/10A61P31/12A61P37/08A61P43/00A61K2300/00
Inventor L·加尼翁P·劳林
Owner PROMETIC BIOSCIENCES LTD
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