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Medicament protecting agent capable of resisting cold, increasing dissolution and resisting oxidation

A protective agent and anti-oxidation technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve problems such as turbidity and unqualified clarity

Inactive Publication Date: 2005-01-26
严家定
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since biochemical drugs use biologically macromolecular proteins, polypeptides, and nucleic acids as biologically active substances, such drugs will have granular precipitation and turbidity during storage and transportation due to low-temperature freezing or repeated freeze-thawing, resulting in poor clarity. qualified

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Accurately weigh the following raw materials: (by weight: gram)

[0022] Macrogol 200 10;

[0023] Tween 20 0.1;

[0024] Sodium bisulfite 0.5;

[0025] Sodium chloride 5;

[0026] Preparation:

[0027] 1. Dissolve the solid sodium bisulfite in an appropriate amount of water for injection (add 10ml of water for injection per gram of sodium bisulfite), after it is completely dissolved, add Tween 80 while stirring, and mix well;

[0028] 2. Add polyethylene glycol 200 into the above solution, and stir until completely mixed (to obtain component A);

[0029] 3. Sodium chloride is separately packaged according to the amount (to obtain component B)

Embodiment 2

[0031] Accurately weigh the following raw materials: (by weight: gram)

[0032] Macrogol 400 80;

[0033] Tween 60 10;

[0034] Sodium sulfite 5;

[0035] Sodium chloride 100;

[0036] Preparation:

[0037] 1, 2, 3 are the same as in Example 1.

Embodiment 3

[0039] Accurately weigh the following raw materials: (by weight: gram)

[0040] Polyethylene glycol 1000 35;

[0041] tween 80 5;

[0042] Sodium bisulfite 2;

[0043] Sodium chloride 60;

[0044] Preparation:

[0045] 1, 2, 3 are the same as in Example 1.

[0046] When in use, the above-mentioned component A and component B are added to the drug injection to be protected according to the usage amount and fully mixed.

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PUM

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Abstract

The invention provides a freeze proof, dissolution increasing, oxidation resisting protector and its preparing process. It is characterized in that it is prepared by the following raw materials in weight portion as: 10%-80% carbowax200 to20000 portions, 0.1%-10% tween 20 to 80 portions, sodium bisulfite or sodium sulfite 0.5 to 5 portions, sodium chloride 5 to 100 portions.The protector can increase the clarity and stability of the biochemical peptide and Chinese herbal injection, thus prevents the problems of cloudiness after low temperature refrigeration in the storage and transportation process.

Description

technical field [0001] The invention relates to the protection technology of medicines, in particular to Chinese herbal medicines, biochemical polypeptide antifreeze, solubilization and antioxidant medicine protection agents and preparation methods thereof. Background technique [0002] Biological and biochemical drugs are biologically active substances prepared from biological tissues, microorganisms, animal toxins, etc., using modern biological techniques or separation and purification techniques, and biological analysis techniques to control the quality of intermediates and products. In the preparation of Chinese herbal medicine injections, except some injections use purified compounds (such as matrine injection, etc.), most of the Chinese herbal medicine injections are not clear about their active ingredients, and the water-alcohol method or alcohol-water method is mainly used to extract their total effective ingredients. ingredients or effective parts, while removing in...

Claims

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Application Information

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IPC IPC(8): A61K47/10A61K47/26
Inventor 严家定
Owner 严家定
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