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Compound spiramycin nanoemulsion oral liquid and preparation method thereof

A technology of spiramycin and milk oral liquid, which is applied in the field of medicine, can solve the problems of low bioavailability and inconvenient use for children, and achieve the effects of simple preparation process, improved sensory quality and good thermodynamic stability

Inactive Publication Date: 2012-06-20
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The bitter taste of spiramycin is obvious when taken orally, and the clinically used dosage forms are often capsules and tablets, which have low bioavailability and are inconvenient to use for those with swallowing difficulties or children

Method used

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  • Compound spiramycin nanoemulsion oral liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Preparation:

[0055] (1) Weigh the surfactant, co-surfactant, oil phase, spiramycin, trimethoprim, and deionized water in the proportion of the formula, and set aside;

[0056] (2) Mix the surfactant and the co-surfactant as the surfactant phase, then add the oil phase and mix;

[0057] (3) Add spiramycin and mix well;

[0058] (4) Add trimethoprim and mix well;

[0059] (5) Slowly add deionized water at room temperature, and stir while adding deionized water until a clear, transparent, colorless or yellowish liquid with low viscosity and good fluidity is formed, which weighs 10 g.

[0060] The formula is as follows:

[0061] Component Content

[0062] Tween-80 2.0 g

[0063] EL-40 0.4g

[0064] Absolute ethanol 0.7 g

[0065] Polyethylene glycol-600 0.05 g

[0066] Ethyl acetate 0.4 g

[0067] Spiramycin 0.6 g

[0068] Trimethoprim 0.15 g

[0069] Deionized water 5.7 g

Embodiment 2

[0070] Example 2 The formula is as follows:

[0071] Component Content

[0072] Poloxamer 188 1.30 g

[0073] EL-40 0.20g

[0074] Absolute ethanol 1.30 g

[0075] Polyethylene glycol-600 0.155 g

[0076] Isopropyl myristate 0.02 g

[0077] Spiramycin 0.02 g

[0078] Trimethoprim 0.005 g

[0079] Deionized water 7.00 g

[0080] Preparation method: with embodiment 1.

Embodiment 3

[0081] Example 3 The formula is as follows:

[0082] Component Content

[0083] EL-40 3.50g

[0084] Absolute ethanol 0.20 g

[0085] 1,2-Propanediol 0.125 g

[0086] Polyethylene glycol-600 0.05 g

[0087] Ethyl acetate 1.0 g

[0088] Spiramycin 0.1 g

[0089] Trimethoprim 0.025 g

[0090] Deionized water 5.0 g

[0091] Preparation method: with embodiment 1.

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Abstract

The invention discloses a compound spiramycin nanoemulsion oral liquid. The particle size of the oral liquid is 1-100nm, and the compound spiramycin nanoemulsion oral liquid comprises the following raw materials in percentage by weight: 15%-35% of surfactant, 3.95%-17.5% of cosurfactant, 0.2%-10% of oil phase, 0.2%-10% of spiramycin, 0.05%-2.5% of trimethoprim and the balance of deionized water, and the sum of the percentages by weight of all the raw materials is 100%. The content of the spiramycin in the nanoemulsion oral liquid can be up to 0.20%-10.00%, the appearance of the compound spiramycin nanoemulsion oral liquid is of colorless or light yellow transparent liquid, the bioavailability of the spiramycin can be significantly improved, and a strong in-vivo antibacterial effect and anantibacterial after effect can be further played. Simultaneously, the stability of a spiramycin medicament is improved, the shortcoming of bitter taste during oral administration of the spiramycin issolved, and the compound spiramycin nanoemulsion oral liquid further has the advantages of high safety, simple preparation and low energy consumption.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of spiramycin with antibacterial effect, in particular to a transparent and stable oil-in-water compound spiramycin nanoemulsion oral liquid and a preparation method thereof. [0002] Background technique [0003] Spiramycin (English name Spiramycin) is a macrolide antibiotic with a broad antibacterial spectrum, strong antibacterial effect in vivo and post-antibacterial effect (PAE). After administration, it is widely distributed in the body, and its concentration is relatively high in viscera (especially the lungs). It has excellent oral administration advantages and can enhance the phagocytosis of phagocytes. The concentration of this product in tissue cells is higher than that of erythromycin, and its side effects are less than that of erythromycin. It has no effect on the liver and will not change the pharmacological effects of other combined drugs. It can be used to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K31/505A61K47/44A61K47/26A61K47/34A61K9/107A61P31/04
Inventor 欧阳五庆周莹欧阳伸雨
Owner NORTHWEST A & F UNIV
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