Unlock instant, AI-driven research and patent intelligence for your innovation.
Compound spiramycin nanoemulsion oral liquid and preparation method thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of spiramycin and milk oral liquid, which is applied in the field of medicine, can solve the problems of low bioavailability and inconvenient use for children, and achieve the effects of simple preparation process, improved sensory quality and good thermodynamic stability
Inactive Publication Date: 2012-06-20
NORTHWEST A & F UNIV
View PDF3 Cites 2 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
The bitter taste of spiramycin is obvious when taken orally, and the clinically used dosage forms are often capsules and tablets, which have low bioavailability and are inconvenient to use for those with swallowing difficulties or children
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0054] Preparation:
[0055] (1) Weigh the surfactant, co-surfactant, oil phase, spiramycin, trimethoprim, and deionized water in the proportion of the formula, and set aside;
[0056] (2) Mix the surfactant and the co-surfactant as the surfactant phase, then add the oil phase and mix;
[0059] (5) Slowly add deionized water at room temperature, and stir while adding deionized water until a clear, transparent, colorless or yellowish liquid with low viscosity and good fluidity is formed, which weighs 10 g.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Property
Measurement
Unit
particle diameter
aaaaa
aaaaa
Login to View More
Abstract
The invention discloses a compound spiramycin nanoemulsion oral liquid. The particle size of the oral liquid is 1-100nm, and the compound spiramycin nanoemulsion oral liquid comprises the following raw materials in percentage by weight: 15%-35% of surfactant, 3.95%-17.5% of cosurfactant, 0.2%-10% of oil phase, 0.2%-10% of spiramycin, 0.05%-2.5% of trimethoprim and the balance of deionized water, and the sum of the percentages by weight of all the raw materials is 100%. The content of the spiramycin in the nanoemulsion oral liquid can be up to 0.20%-10.00%, the appearance of the compound spiramycin nanoemulsion oral liquid is of colorless or light yellow transparent liquid, the bioavailability of the spiramycin can be significantly improved, and a strong in-vivo antibacterial effect and anantibacterial after effect can be further played. Simultaneously, the stability of a spiramycin medicament is improved, the shortcoming of bitter taste during oral administration of the spiramycin issolved, and the compound spiramycin nanoemulsion oral liquid further has the advantages of high safety, simple preparation and low energy consumption.
Description
technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of spiramycin with antibacterial effect, in particular to a transparent and stable oil-in-water compound spiramycin nanoemulsion oral liquid and a preparation method thereof. [0002] Background technique [0003] Spiramycin (English name Spiramycin) is a macrolide antibiotic with a broad antibacterial spectrum, strong antibacterial effectin vivo and post-antibacterial effect (PAE). After administration, it is widely distributed in the body, and its concentration is relatively high in viscera (especially the lungs). It has excellent oral administration advantages and can enhance the phagocytosis of phagocytes. The concentration of this product in tissue cells is higher than that of erythromycin, and its side effects are less than that of erythromycin. It has no effect on the liver and will not change the pharmacological effects of other combined drugs. It can be used to...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
