Submicron emulsion injection liquid of CoQ10 and preparation process thereof

A sub-microemulsion and injection technology, applied in the fields of health care products and medicines, can solve problems such as application difficulties, unstable injection, and increased side effects.

A sub-microemulsion and injection technology, applied in the fields of health care products and medicines, can solve problems such as application difficulties, unstable injection, and increased side effects.

CN1965805AActive Publication Date: 2007-05-23SHENYANG WANJIA INST OF BIOLOGICAL TECH RES +1
2 Cites 13 Cited by

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Submicron emulsion injection liquid of CoQ10 and preparation process thereof
  • Submicron emulsion injection liquid of CoQ10 and preparation process thereof
  • Submicron emulsion injection liquid of CoQ10 and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Coenzyme Q of the present invention 10 Submicroemulsion injection is composed of the following raw materials in weight ratio:

[0047] coenzyme Q 10 : soybean oil: lecithin: glycerin: water for injection = 0.1:7:0.5:2:89;

[0048] Weigh coenzyme Q according to the above weight ratio 10 1g, join in the 70g injection grade soybean oil (Tieling City Beiya Medicinal Oil Company), make dissolving; 5g refined egg yolk lecithin (German lipoid company) is dispersed in 100g water; Apparatus factory) with 10000rpm, mix and homogenize for 2-5 minutes, add 790g water for injection, 20g glycerol, with 10000rpm, homogenize for 3-5 minutes, form colostrum, colostrum is joined in high-pressure milk homogenizer (Italian ATS company ), pass N 2 Protection, the initial pressure is 20-30MPa, circulate for 2 minutes, then increase to 80-100Mpa, circulate 6 times, release homogeneous milk. In the 100-level purification workshop, microporous membrane equipment is used to pass through a 0...

Embodiment 2

[0050] Coenzyme Q of the present invention 10 Submicroemulsion injection is composed of the following raw materials in weight ratio:

[0051] coenzyme Q 10 : soybean oil: lecithin: glycerin: oleic acid: water for injection = 2:30:3:2.5:1:65;

[0052] Take coenzyme Q according to the above weight ratio 10 20g, join in 300g injection grade soybean oil, make dissolving, oleic acid 10g; 30g refined egg yolk lecithin (German lipoid company) is dispersed in 150g water; , mix and homogenize for 2-5 minutes, add 500g water for injection, 25g glycerin, and homogenize for 3-5 minutes at 15000rpm to form colostrum, then, use a high-pressure homogenizer, under a pressure of 20MPa, pass N 2 Protected, after 1 cycle, a uniform emulsion is formed. All the other are with embodiment 1. As determined by liquid chromatography, contains coenzyme Q 10 18mg / ml, the emulsion particle size below 1000nm is greater than 85%.

Embodiment 3

[0054] Coenzyme Q of the present invention 10 Submicroemulsion injection is composed of the following raw materials in weight ratio:

[0055] coenzyme Q 10 : soybean oil: lecithin: glycerin: oleic acid: water for injection = 1:17:2:2.2:0.5:75;

[0056] Weigh coenzyme Q according to the above weight ratio 10 10g, join in 170g injection grade soybean oil, make dissolving, oleic acid 5g; 20g refined egg yolk lecithin (German lipoid company) is dispersed in 200g water; , mix and homogenize for 2-5 minutes, add 550g water for injection, 22g glycerin, and homogenize for 3-5 minutes at 20000rpm to form colostrum, then, use a high-pressure homogenizer, under a pressure of 60MPa, pass N 2 Protected, after 5 cycles, a uniform emulsion was formed. All the other are with embodiment 1. As determined by liquid chromatography, contains coenzyme Q 10 11mg / ml, 1000nm emulsion is greater than 93%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to a method for preparing coenzyme Q10 sub micro-emulsion injection, wherein said agent can treat cardiovascular disease, hepatitis, etc, while it can be injected or orally taken. And it comprises coenzyme Q10, soya oil, lecithin, glycerin, and injection water at 0.1-2:7-30:0.5-3:2-2.5:0-1:65-89; it uses high-speed mixer or ultrasonic vibration to form initial emulsion, via high-pressure mixer to prepare coenzyme Q10 sub micro-emulsion. Said agent is water-packing-oil sub micro emulsion, which packs coenzyme in water-packing-oil micro oil to reduce excited reaction and side effect, with target function.

Description

technical field [0001] The present invention relates to a kind of coenzyme Q 10 Submicroemulsion injection and preparation method thereof, the preparation has good therapeutic effect on diseases such as cardiovascular diseases, hepatitis, low immunity, etc., can be injected or taken orally, and belongs to the technical field of medicines and health care products. Background technique [0002] coenzyme Q 10 Also known as ubiquinone, also known as decenoquinone, ubiquinone alcohol, vitamin Q, vitamin coenzyme Q, the English name is Coenzyme Q 10 , Ubiquinone, molecular formula C 59 h 90 o 4 . This substance is the body's own substance, and it also widely exists in the animal heart and other organs. It can be extracted from the animal heart, and can also be obtained through chemical synthesis and biosynthesis. coenzyme Q 10 It is an indispensable and important physiological substance in the human body. Its chemical structure characteristics determine that it has many imp...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
23 May 2007
Publication
CN1965805A
IPC
A61K9/107; A61K31/122; A61P3/02
Inventors
董英杰; 艾莉