Anthocyanin phospholipids compound and preparation method thereof

A technology for glycoside phospholipids and complexes, which is applied in the field of anthocyanin phospholipid complexes and their preparation, can solve the problems of low bioavailability and unfavorable application of medicinal preparations, and achieves improved lipid solubility, good slow release characteristics, and good mucosal permeability. Transient effects

Inactive Publication Date: 2009-09-23
SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Anthocyanins usually have low bioavailability, which is not conducive to the application of certain medicinal preparations

Method used

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  • Anthocyanin phospholipids compound and preparation method thereof
  • Anthocyanin phospholipids compound and preparation method thereof
  • Anthocyanin phospholipids compound and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take 50mg of black rice anthocyanins, add 200ml of 95% ethanol, add 100mg of soybean lecithin, heat to 60°C under reflux and stir to react for 2 hours, remove the ethanol under reduced pressure, and dry under conventional low-temperature vacuum to obtain solid anthocyanin-phospholipid complex.

Embodiment 2

[0028] Take 100mg of bilberry anthocyanin, add 500ml of tetrahydrofuran, add 2000mg of soybean lecithin, heat to 50°C and reflux, stir and react for 2 hours, remove the reaction solvent tetrahydrofuran under reduced pressure, and dry in vacuum at low temperature to obtain a solid anthocyanin-phospholipid complex.

[0029] The tetrahydrofuran can be replaced by any one of ethyl acetate, propanol or butanol or their mixture in any proportion.

Embodiment 3

[0031] Take 100mg of grape anthocyanin, add 200ml of acetone, add 1000mg of egg yolk phospholipid, heat to 60°C and reflux, stir and react for 1 hour, remove the reaction solvent acetone under reduced pressure, add n-hexane to dissolve, filter, recover the solvent n-hexane from the filtrate under reduced pressure, and keep the residue at low temperature Vacuum drying to obtain anthocyanin phospholipid complex.

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Abstract

The invention discloses an anthocyanin phospholipids compound and a preparation method thereof, comprises an anthocyanin phospholipids compound and a preparation method thereof, and belongs to the field of medicaments and health-care products. The components of the anthocyanin phospholipids compound comprise anthocyanin and phospholipids, wherein the weight ratio of the anthocyanin to the phospholipids is 1:1-20; and the preparation method adopts an organic solvent with a small dielectric constant for dissolving a mixture of the anthocyanin and the phospholipids and prepares the anthocyanin phospholipids compound through solvent evaporation and other technical processes. The anthocyanin phospholipids compound has the advantages of lipid solubility, easy absorption, high bioavailability, emulation formulation, and the like.

Description

technical field [0001] The invention relates to anthocyanin phospholipid complex and a preparation method thereof, including anthocyanin phospholipid complex and a preparation method thereof, and belongs to the field of medicine and health products. Background technique [0002] Anthocyanin (anthocyanin) is a kind of water-soluble pigment widely present in plants, also known as anthocyanin or anthocyanin, which is the main coloring substance of plants, and anthocyanin is also abundant in nature A water-soluble plant pigment substance, the chemical structure is glycoside of 2-phenylpropanol polyhydroxyl or polymethoxyl substituted, it is a kind of flavonoid substance, usually including geranium pigment, cyanidin, fly Chemical components of larkspur pigment, peony pigment, petunia pigment, mallow pigment, representative components are anthocyanidin-3-O-glucoside (C3G), anthocyanidin rhamnoside, anthocyanidin arabic Glycosides, anthocyanin galactosides. Sources of anthocyanin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61K31/7048A61K47/24A61P39/06
CPCA61K31/7048A23L1/3008A61K9/107A23L1/3002A23L33/105A23L33/12A61P1/04A61P3/06A61P27/02A61P35/00A61P37/08A61P39/06
Inventor 董英杰艾莉穆英俊
Owner SHENYANG WANJIA INST OF BIOLOGICAL TECH RES
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