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Traditional Chinese medicine slow-releasing medicine for treating cardiovascular disease and its preparation method

A technology of cardiovascular and sustained-release agents, which is applied in the field of traditional Chinese medicine sustained-release agents for the treatment of cardiovascular diseases and its preparation, can solve the problems of large fluctuations in blood drug concentration, low content of active ingredients in traditional Chinese medicine, and inability to show curative effects, etc., to achieve increased Coronary blood flow, long-lasting and safe efficacy, and the effect of reducing the number of medications

Inactive Publication Date: 2005-03-23
DONGLING MEDICINES INST SHENYANG CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the side effects of Chinese patent medicines are small, due to the low content of active ingredients in traditional Chinese medicines, the dosage is relatively large, and some medicines have a short half-life in the human body, so they need to be administered several times a day, which is not only inconvenient to take, but also easy to miss doses
What is more serious is that the drug concentration in the blood fluctuates greatly due to multiple administrations, and there are peaks and valleys. When the blood concentration is high, it will exceed the therapeutic concentration range and increase side effects. When it is low, it is below the effective therapeutic concentration, so that it cannot show curative effect

Method used

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  • Traditional Chinese medicine slow-releasing medicine for treating cardiovascular disease and its preparation method
  • Traditional Chinese medicine slow-releasing medicine for treating cardiovascular disease and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The sustained-release agent of the present invention is composed of the following raw and auxiliary materials by weight:

[0049] Total flavonoids of Epimedium: Microcrystalline Cellulose: Sodium Carboxymethyl Starch: Hydroxypropyl Methyl Cellulose: Magnesium Stearate=60:27:9:8:1

[0050] The method of making it into a tablet comprises the following steps:

[0051] a. Take Epimedium herbs, chop them, add water to decoct twice, add 20 times the amount of water for the first time, decoct for 2 hours, add 10 times the amount of water for the second time, decoct for 2 hours, combine and filter the decoction, and concentrate the filtrate To the relative density of 1.10 (80 ℃), add ethanol to the alcohol content of 70%, stand, filter or centrifuge, the filtrate is decompressed to recover ethanol, and concentrated to a clear paste with a relative density of 1.10, add 10 times the amount of 10% sodium carbonate (Na 2 CO 3 ) aqueous solution, stirred, filtered or centrifuged,...

Embodiment 2

[0055] The sustained-release agent of the present invention is composed of the following raw and auxiliary materials by weight:

[0056] Total flavonoids of Epimedium: microcrystalline cellulose: sodium carboxymethyl starch: hydroxypropyl methyl cellulose: magnesium stearate=45:30:8:25:3.

[0057] The method for preparing it into a tablet is the same as that in Example 1.

Embodiment 3

[0059] The sustained-release agent of the present invention is composed of the following raw and auxiliary materials by weight:

[0060] Epimedium total flavonoids: microcrystalline cellulose: sodium carboxymethyl starch: hydroxypropyl methyl cellulose: magnesium stearate = 90:5:1:1:0.1.

[0061] The preparation method is the same as that in Example 1.

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Abstract

A slow-releasing Chinese medicine for treating coronary heart disease and angia pectoris and lowering blood pressure is prepared from epimedium, microcrystalline cellulose, carboxymethyl starch sodium, hydroxypropyl methyl cellulose and magnesium stearate.

Description

technical field [0001] The present invention relates to a traditional Chinese medicine for treating cardiovascular diseases, in particular to a traditional Chinese medicine slow-release preparation for treating cardiovascular diseases and a preparation method thereof. Background technique [0002] Coronary heart disease and angina pectoris are common clinical diseases, which are roughly equivalent to "chest pain" in Chinese medicine, which refers to a disease characterized by chest tightness, even chest pain, shortness of breath, and inability to lie down for wheezing. TCM syndrome differentiation of chest arthralgia can be divided into "heart-blood stasis syndrome", "phlegm congestion syndrome", "yin-cold stagnation syndrome", "heart-kidney yin deficiency syndrome", "qi and yin deficiency syndrome", and "yang-qi deficiency syndrome". (Refer to the "Clinical Guidelines for New Chinese Medicines"). The chest pain involved in the present invention belongs to the "Yang-qi defi...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61P9/10
Inventor 熊英
Owner DONGLING MEDICINES INST SHENYANG CITY
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