Traditional Chinese medicine slow-releasing medicine for treating cardiovascular disease and its preparation method
A technology of cardiovascular and sustained-release agents, which is applied in the field of traditional Chinese medicine sustained-release agents for the treatment of cardiovascular diseases and its preparation, can solve the problems of large fluctuations in blood drug concentration, low content of active ingredients in traditional Chinese medicine, and inability to show curative effects, etc., to achieve increased Coronary blood flow, long-lasting and safe efficacy, and the effect of reducing the number of medications
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Embodiment 1
[0048] The sustained-release agent of the present invention is composed of the following raw and auxiliary materials by weight:
[0049] Total flavonoids of Epimedium: Microcrystalline Cellulose: Sodium Carboxymethyl Starch: Hydroxypropyl Methyl Cellulose: Magnesium Stearate=60:27:9:8:1
[0050] The method of making it into a tablet comprises the following steps:
[0051] a. Take Epimedium herbs, chop them, add water to decoct twice, add 20 times the amount of water for the first time, decoct for 2 hours, add 10 times the amount of water for the second time, decoct for 2 hours, combine and filter the decoction, and concentrate the filtrate To the relative density of 1.10 (80 ℃), add ethanol to the alcohol content of 70%, stand, filter or centrifuge, the filtrate is decompressed to recover ethanol, and concentrated to a clear paste with a relative density of 1.10, add 10 times the amount of 10% sodium carbonate (Na 2 CO 3 ) aqueous solution, stirred, filtered or centrifuged,...
Embodiment 2
[0055] The sustained-release agent of the present invention is composed of the following raw and auxiliary materials by weight:
[0056] Total flavonoids of Epimedium: microcrystalline cellulose: sodium carboxymethyl starch: hydroxypropyl methyl cellulose: magnesium stearate=45:30:8:25:3.
[0057] The method for preparing it into a tablet is the same as that in Example 1.
Embodiment 3
[0059] The sustained-release agent of the present invention is composed of the following raw and auxiliary materials by weight:
[0060] Epimedium total flavonoids: microcrystalline cellulose: sodium carboxymethyl starch: hydroxypropyl methyl cellulose: magnesium stearate = 90:5:1:1:0.1.
[0061] The preparation method is the same as that in Example 1.
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