Andrographolide dispersed tablet and preparation method thereof

A technology of andrographolide and dispersible tablets, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., can solve the problems of slow dissolution, long disintegration time of ordinary tablets, slow onset of action, etc., and achieve effective Quick effect, good taste, convenient to take

Inactive Publication Date: 2005-06-22
韩渤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Andrographolide tablets have been recorded in the 19th volume of traditional Chinese medicine prescriptions. They are ordinary tablets made of andrographolide. This ordinary tablet has a long disintegration time and a slow dissolution rate. The dissolution rate reaches 80% in 120 minutes. slower

Method used

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  • Andrographolide dispersed tablet and preparation method thereof
  • Andrographolide dispersed tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] One, the preparation of andrographolide dispersible tablet

[0047] Andrographolide 50g

[0048] Lactose 170g

[0049] Microcrystalline Cellulose 150g

[0050] Hypromellose (low substitution) 60g

[0051] Crospovidone 50g

[0052] Stevia 10g

[0053] 95% ethanol 80ml

[0054] Micronized silica gel 6g

[0055] Magnesium Stearate 3g

[0056] Makes 1000 pieces

[0057] 2. Preparation process

[0058] 1. Preparation method: crush the raw and auxiliary materials through a 100-mesh sieve, weigh the purchased raw materials andrographolide, lactose, microcrystalline cellulose, hydroxypropyl cellulose (low substitution), crospovidone, and stevia according to the prescription amount Mix well, add 95% ethanol to make soft material, use 18-mesh sieve to granulate the soft material, dry the wet granules at 50°C, granulate with 18-mesh sieve after drying, add micropowder silica gel and magnesium st...

Embodiment 2

[0060] One, the preparation of andrographolide dispersible tablet

[0061] Andrographolide 25g

[0062] Lactose 50g

[0063] Microcrystalline Cellulose 50g

[0064] Hypromellose (low substitution) 20g

[0065] Crospovidone 20g

[0066] Stevia 20g

[0067] 95% ethanol 40ml

[0068] Micronized silica gel 2g

[0069] Magnesium Stearate 2g

[0070] Makes 1000 pieces

[0071] 2. Preparation process

[0072] 1. Preparation method: crush the raw and auxiliary materials through a 100-mesh sieve, weigh the purchased raw materials andrographolide, lactose, microcrystalline cellulose, hydroxypropyl cellulose (low substitution), crospovidone, and stevia according to the prescription amount Mix well, add 95% ethanol to make soft material, use 18-mesh sieve to granulate the soft material, dry the wet granules at 50°C, granulate with 18-mesh sieve after drying, add micropowder silica gel and magnesium st...

Embodiment 3

[0074] One, the preparation of andrographolide dispersible tablet

[0075] Andrographolide 100g

[0076] Lactose 200g

[0077] Microcrystalline Cellulose 250g

[0078] Hypromellose (low substitution) 150g

[0079] Crospovidone 150g

[0080] Stevia 20g

[0081] 95% ethanol 200ml

[0082] Micronized silica gel 20g

[0083] Magnesium Stearate 10g

[0084] Makes 1000 pieces

[0085] 2. Preparation process

[0086] 1. Preparation method: crush the raw and auxiliary materials through a 100-mesh sieve, weigh the purchased raw materials andrographolide, lactose, microcrystalline cellulose, hydroxypropyl cellulose (low substitution), crospovidone, and stevia according to the prescription amount Mix well, add 95% ethanol to make soft material, use 18-mesh sieve to granulate the soft material, dry the wet granules at 50°C, granulate with 18-mesh sieve after drying, add micropowder silica gel and magn...

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Abstract

The invention discloses an andrographolide dispersed tablet and preparation method, wherein the tablet is prepared from andrographolide and pharmaceutical carrier, the prescription for each 1000 dispersed tablets includes, andrographolide 50-100g, lactose 50-200g, crystalline cellulose 50-250g, low substituted methylcellulose propylene glycol ether 20-150g, crosslinked povidone 20-150g, stevioside 2-20g, right amount of 95% ethanol, silica gel powder 2-20g, magnesium stearate 2-10, the invention has the advantages of good taste, convenient in use, quick action, and can be used for treating diseases including respiratory tract infection and bacteria dysentery.

Description

【Technical field】 [0001] The invention relates to a new pharmaceutical preparation of traditional Chinese medicine andrographolide and its formulation composition, in particular to andrographolide dispersible tablets and a preparation method thereof. 【Background technique】 [0002] Andrographolide tablets have been recorded in the 19th volume of traditional Chinese medicine prescriptions. They are ordinary tablets made of andrographolide. This ordinary tablet has a long disintegration time and a slow dissolution rate. The dissolution rate reaches 80% in 120 minutes. The effect is slower. The present invention makes andrographolide into a new dosage form of dispersible tablets, so that the active ingredient of the drug andrographolide can be quickly disintegrated and reach a uniformly dispersed state, the active ingredients can be dissolved quickly, and the mouthfeel can be improved by adding a flavoring agent. Take it orally after dispersing in water, suitable for the elder...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/365A61P1/00A61P11/00A61P31/04
CPCY02A50/30
Inventor 韩渤腾健
Owner 韩渤
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