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Swerianmarin injectio, its preparation process and application

A picroside injection and the technology of lepharoside, which is applied to picroside injection and the field of preparation and application thereof, can solve the problems of no specific medicine and the like, achieve less toxic and side effects, resist liver damage, and have abundant medicinal resources. Effect

Inactive Publication Date: 2005-07-06
昆明同持医药研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no specific drug for chronic hepatitis, especially chronic hepatitis B and multiple cross-infection compound hepatitis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Weigh 100g of swertiamarin and 50g of mannitol, add 3000ml of water for injection to dissolve, keep warm at 40℃~45℃ for 20 minutes, cool to room temperature, add water for injection to dilute to 5000ml, and the filtrate is at 0℃~5℃ Put it in the refrigerator for 12 hours, filter with 0.45μm microporous membrane; dilute to 10000ml with water for injection, filter with 0.2μm microporous membrane, potting (5ml / bottle), freeze-dry, sterilize by radiation, and pack.

Embodiment 2

[0043] Weigh 100g swertiamarin, 20g each of mannitol and vitamin C, add 5000ml of water for injection to dissolve, keep warm at 45°C-50°C for 20 minutes, cool, and filter through a 0.45μm microporous membrane; Place at 5°C for 24 hours, dilute to 10,000ml with water for injection, filter with 0.2μm microporous membrane, ultrafiltration membrane (molecular weight cut-off 10,000), potting (5ml / bottle), freeze-dry, and pack.

Embodiment 3

[0045] Weigh 100g of swertiamarin and 100g of mannitol, add 5000ml of water for injection to dissolve, keep warm at 40°C-45°C for 20 minutes, cool, filter with 0.45μm microporous membrane, 0.2μm microporous membrane, The filtrate was placed at 0°C to 5°C for 24 hours, diluted with water for injection to 10,000ml, filtered through a 0.1μm microporous membrane, ultrafiltration membrane (molecular weight cut-off 6000), potting (5ml / bottle), freeze-dried, and packaged. Can.

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PUM

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Abstract

The invention discloses a Swerianmarin injection, its preparation process and application, wherein the preparing process comprises using Gentianaceae, Scrophulariaceae or Oleaceae plants as raw material, employing conventional phytochemical method for extraction, segregation and purification, thus obtaining swertiamarin, weighing swertiamarin and medicinal adjuvant, charging water for injection, thermal insulating 10-20 minutes at 30-60 deg. C, cooling down, filtering, dispensing the filter liquor 1-48 hours at 0-5 deg. C, filtering, encapsulating, drying in frozen, sterilizing, and packaging.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and its preparation method and application. Background technique [0002] Hepatitis is a self-limiting disease. After getting the disease, provide appropriate treatment and rest. In most cases, the body will gain immunity and recover. However, in the acute stage of the disease attack or the acute stage of chronic hepatitis, improper treatment or other reasons lead to the deterioration or delay of the disease, which will make the virus resistant to the body's immune antibodies, avoid the body's clearance of the virus or slow down the clearance of the virus. Increase the incidence of chronic hepatitis, thereby leading to diseases such as liver cirrhosis and liver cancer, bringing life-long suffering to patients. Therefore, for hepatitis, especially viral hepatitis, early treatment is very critical and important. [0003] There are 28 million chronic hepatitis patients with he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7048A61P1/06A61P1/16
Inventor 周春香
Owner 昆明同持医药研究有限公司
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