Traditional Chinese medicine composition for treating hepatic fibrosis as well as preparation method and application thereof

A technology of liver fibrosis and composition, which is applied in the field of traditional Chinese medicine composition for treating liver fibrosis and its preparation, can solve the problems of high cost, achieve safe and reliable administration, reduce liver tissue lesions, and block the progress of the disease

Active Publication Date: 2022-03-11
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional Chinese medicine composition formula for treating liver disease in the prior art mostly uses famous and expensive medicinal materials, and the cost is high. Therefore, providing a relatively cheap Chinese medicine composition for treating liver disease is of great significance for the clinical application of Chinese medicine for treating liver disease.

Method used

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  • Traditional Chinese medicine composition for treating hepatic fibrosis as well as preparation method and application thereof
  • Traditional Chinese medicine composition for treating hepatic fibrosis as well as preparation method and application thereof
  • Traditional Chinese medicine composition for treating hepatic fibrosis as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Take 15g of Scutellaria baicalensis and 15g of Radix Paeoniae Rubra, add 10 times the amount of distilled water, soak for 0.5h, decoct and extract 3 times with 10 times the amount of water each time, decoct and extract for 2 hours; filter, combine and concentrate the filtrate three times to 0.44g / ml The extract was obtained, and 1 g of the extract was equivalent to 3.90 g of crude drug, which was labeled as a sample of Scutellaria baicalensis-Red Paeoniae Rubra (1:1).

Embodiment 2

[0038]Take 15g of Scutellaria baicalensis and 30g of Radix Paeoniae Rubra, add 10 times the amount of distilled water, soak for 0.5h, decoct and extract 3 times with 10 times the amount of water each time, decoct and extract for 2 hours; filter, combine and concentrate the filtrate three times to 0.44g / ml The extract was obtained, and 1 g of the extract was equivalent to 2.99 g of crude drug, which was labeled as a sample of Scutellaria Radix-Red Paeoniae Rubra (1:2).

Embodiment 3

[0040] Take 15g of Scutellaria baicalensis and 60g of Radix Paeoniae Rubra, add 10 times the amount of distilled water, soak for 0.5h, decoct and extract 3 times with 10 times the amount of water each time, decoct and extract for 2 hours; filter, combine and concentrate the filtrate three times to 0.44g / ml The extract was obtained, and 1 g of the extract was equivalent to 2.98 g of crude drug, which was labeled as a sample of Scutellaria baicalensis-Red Paeoniae Rubra (1:4).

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Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hepatic fibrosis and a preparation method and application thereof. The traditional Chinese medicine composition for treating hepatic fibrosis is prepared from radix scutellariae and radix paeoniae rubra. Wherein the mass ratio of the radix scutellariae to the radix paeoniae rubra is 1: (1-4). Pharmacological experiment results show that the traditional Chinese medicine composition can intervene in a hepatic fibrosis rat model, the concentration of serological indexes ALT, AST, HA, LN, AKP and ALB is remarkably reduced, the level content of SOD, MDA and Hyp in hepatic tissue is reduced, hepatic tissue pathology influences HE, and Masson staining shows that the degree of hepatic fibrosis can be reduced. The pharmaceutical composition disclosed by the invention has the effect of improving hepatic fibrosis, is safe and reliable to take, free from toxic and side effects, proper in compatibility, and remarkable in curative effect on hepatic fibrosis, and provides a new choice for clinical treatment, and the medicines supplement each other. The method has a wide application prospect for high morbidity of hepatopathy in China.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating liver fibrosis, a preparation method and application thereof. Background technique [0002] Hepatic fibrosis (Hepatic fibrosis, HF) is a histopathological concept. At present, pathological studies mainly believe that liver damage leads to inflammation and necrosis of liver cells, resulting in unbalanced proliferation and decomposition of fibrous tissue in the liver, excessive deposition of fibrous connective tissue in the liver, and activation of hepatic stellate cells. Extracellular matrix (Extracellular mat-rix, ECM) hyperplasia and abnormal deposition, metabolic disorders, and finally lead to liver fibrosis. As a result, the liver tissue structure is destroyed, affecting the blood supply of liver cells. In severe cases, it gradually develops into liver cirrhosis and even liver cancer, seriously affe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61P1/16
CPCA61K36/539A61K36/71A61K36/65A61P1/16A61K2236/331A61K2236/39A61K2300/00Y02A50/30
Inventor 陈平平南洋刘树民张敬博吴娟卢意刘苏杰
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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