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Preparation process of minium red freeze dried powder for injection

A preparation process and injection technology, applied in the field of preparation technology of Danhong lyophilized powder for injection, can solve the problems of poor quality control of finished products, low utilization rate of raw materials, improved product quality, etc., and achieve low impurity content and finished product quality. High, Difficulty-Reducing Effect

Inactive Publication Date: 2005-08-10
陕西华森生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a preparation process of Danhong freeze-dried powder for injection, to overcome the problems of low raw material utilization rate, high cost, poor quality control of finished products and unfavorable improvement of product quality existing in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: including the following steps in turn, A, water extraction: take the above two medicinal materials, the salvia miltiorrhiza is crushed into a coarse powder and mixed with safflower, add 12 times of water and soak twice at 65 ° C, each time for one hour, and combine the filtrates, Filter, and the filtrate is concentrated to a clear paste with a relative density of 1.20 (65°C); B, alcohol precipitation: add ethanol to make the solution alcohol content reach 70%, stir well, refrigerate for 20 hours, filter, reclaim the ethanol from the filtrate, and concentrate to The clear ointment whose relative density is 1.10 (65°C); C, resin removal: add hydrochloric acid in the clear ointment to adjust the pH value to 2.5, refrigerate for 60 hours, and filter; D, adjust isotonicity: add water for injection to the filtrate to a specified amount, adjust When the pH value reaches 6.5, add sodium chloride for injection to adjust to isotonicity; E. Finished product processing...

Embodiment 2

[0020] Embodiment 2: Include the following steps successively, A, water extraction: take the above two kinds of medicinal materials, Danshen is crushed into coarse powder and mixed with safflower, add 8 times of water and soak twice at 65 ° C, each time for 1.2 hours, and combine the filtrates, Filter, the filtrate is concentrated to a clear paste with a relative density of 1.10 (65°C); B, alcohol precipitation: add ethanol to make the solution alcohol content reach 75%, stir well, refrigerate for 24 hours, filter, reclaim ethanol from the filtrate, and concentrate to Clear cream with a relative density of 1.05 (65°C); F, precipitation step: add 0.3% egg white solution to the clear cream, stir while adding, until no precipitation occurs, stand still for 1.2 hours, filter, heat and boil for 40 minutes , let cool; G, secondary alcohol precipitation: add ethanol to make the alcohol content of the solution reach 85%, stir well, refrigerate for 24 hours, filter, recover ethanol from...

Embodiment 3

[0021] Embodiment 3: including the following steps in turn, A, water extraction: take the above two medicinal materials, the salvia miltiorrhiza is crushed into coarse powder and mixed with safflower, add 10 times of water and soak twice at 60 ° C, each time for one hour, and combine the filtrates, Filter, the filtrate is concentrated to a clear paste with a relative density of 1.10 (65°C); B, alcohol precipitation: add ethanol to make the solution alcohol content reach 75%, stir well, refrigerate for 24 hours, filter, reclaim ethanol from the filtrate, and concentrate to Clear cream with a relative density of 1.15 (65°C); F, precipitation: add 0.1% egg white solution to the clear cream, stir while adding, until no precipitation occurs, stand still for 2 hours, filter, heat and boil for 30 minutes, Let cool; G, secondary alcohol precipitation: add ethanol to make the alcohol content of the solution reach 85%, stir well, refrigerate for 24 hours, filter, recover ethanol from the...

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Abstract

A freeze dried powder injection is prepared from red sage root and safflower through pulverizing red sage root, proportionally mixing it with safflower, immersing in warm water, filtering, concentrating, depositing in alcohol, regulating pH value, cold storage, filtering, adding water for injection, regulating pH value, adding sodium chloride, and freeze drying.

Description

Technical field: [0001] The invention relates to the technical field of preparation technology of traditional Chinese medicine, in particular to a preparation technology of Danhong freeze-dried powder for injection. Background technique: [0002] Danhong injection is a traditional Chinese patent medicine that has been used for 20 years. Its medicinal ingredients are Danshen and safflower. In the "National Drug Standards (Trial) Promulgation", the published prescription is Danshen 750g , 250g of safflower, 7g of sodium chloride for injection, and made into a 1000ml finished product; in the promulgation, the preparation process of Danhong injection was also announced. Soak twice, 1 hour each time, filter, and use the filtrate for later use; mix the dregs with safflower, add warm water to soak twice, 1 hour each time, filter, combine the filtrates, and concentrate to a relative density of 1.10-1.20 (65°C ) clear ointment, add sodium chloride for injection to isotonicity, adjus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19
Inventor 何博
Owner 陕西华森生物医药科技有限公司
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