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Purified amylase inhibitor and novel process for obtaining the same

An amylase inhibitor and rehydration technology, applied in amylase inhibitors, postprandial glucose tolerance of mammals, and enzymes that decompose starch, can solve problems such as insolubility, loss of potency, and instability

Inactive Publication Date: 2005-09-07
PHARMACHEM LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some reasons have been suggested that currently commercially available amylase inhibitors are unstable in the gastrointestinal tract due to pH, are insoluble in water, and / or lose potency due to the use of solvents and heat treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Purification of Amylase Inhibitors by Spray Drying

[0056] 1. Grinding

[0057] All dried non-GMO beans were checked for cleanliness. After confirmation of the quality control of the beans, 1000g of dried beans are put into Fitzpatrick  in the grinder. A #4 screen (process mill size) was used in this mill. Grinding continues until the beans are the right size.

[0058] 2. Extraction

[0059] Coarsely ground beans are placed in an extraction tube and then 2 to extract. The extraction process is carried out under vacuum pressure at a temperature of about 145°F for about 2 hours. Supercritical CO 2 Impurities (eg, lipids, oils, fats, and spices, etc.) are removed from the roughly ground beans while leaving the beans in pieces.

[0060] Then reduce the pressure in the extraction tube. The reduction in pressure causes impurities in the beans to precipitate out of the supercritical solution and into the separator.

[0061] 3. Heat preservation

[0062] At a temp...

Embodiment 2

[0071] Purification of amylase inhibitors by freeze-drying

[0072] 1. Grinding

[0073] All dried non-GMO beans are checked for cleanliness. After confirmation of the quality control of the beans, 1000g of dried beans are put into Fitzpatrick  in the grinder. A #4 screen (process mill size) was used in this mill. Grinding is continued until the beans have reached the proper size.

[0074] 2. Extraction

[0075] Coarsely ground beans are placed in an extraction tube and then 2 to extract. The extraction process is carried out under vacuum pressure at a temperature of about 145°F for about 2 hours. Supercritical CO 2 Impurities (eg, lipids, oils, fats, and spices, etc.) are removed from the roughly ground beans while leaving the beans in pieces.

[0076] Then reduce the pressure in the extraction tube. The reduction in pressure causes impurities in the beans to precipitate out of the supercritical solution and into the separator.

[0077] 3. Heat preservation

[0078...

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PUM

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Abstract

The present invention provides a purified amylase inhibitor obtained by a superior process that includes extracting ground beans with supercritical carbon dioxide. The invention also provides a method for inducing weight loss in a mammal in need thereof comprising administering to the mammal, an effective amount of an amylase inhibitor obtained by the superior process. A method for improving post-prandial glucose tolerance in a diabetic mammal comprising administering to the mammal, an effective amount of an amylase inhibitor obtained by the superior process, is also provided.

Description

Background technique [0001] Amylase is an enzyme used to break down a major source of carbohydrates in the human diet, namely starch. Digestion of starch begins in the mouth, where the glycosidic bonds of starch are hydrolyzed by alpha-amylase present in saliva. [0002] By the time thoroughly chewed food reaches the stomach, the average chain length of starch has been reduced from a few thousand glucose units to less than eight glucose units. The acid concentration in the stomach inactivates salivary alpha-amylase. Further digestion of starch continues in the small intestine by pancreatic alpha-amylase similar to that of salivary alpha-amylase. [0003] For example, reducing carbohydrate absorption by inhibiting starch digestion is a very promising strategy in the fields of weight loss and diabetes. From a dietary standpoint, it is important to target the breakdown of starch since it is a relatively non-essential nutrient providing few beneficial calories. [0004] Amylas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A23LA61K36/00A61P3/00A61P3/04A61P43/00
CPCC07K14/4703A61K36/48A61P3/00A61P3/04A61P43/00Y02P20/54
Inventor 米切尔·什科普迪利普·肖科希
Owner PHARMACHEM LAB INC
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