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Zedoary oil injecting emulsion and preparation thereof

A technology of zedoary oil and emulsion, which can be used in antiviral agents, pharmaceutical formulations, emulsion delivery, etc., and can solve the problems of human cardiovascular and cerebrovascular toxicity.

Inactive Publication Date: 2005-10-12
肖春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the use of Tween substances in injection preparations, especially in traditional Chinese medicine injection preparations, can cause toxic reactions in the human cardiovascular and cerebrovascular systems.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Dissolve 8.0g of zedoary oil, 12g of refined soybean lecithin in 100g of refined soybean oil, dissolve 22.5g of glycerin in water for injection, heat to 55°C respectively, mix well, disperse and emulsify in a tissue masher first, and then Emulsify with a homogenizer until the milk particles meet the requirements of the Pharmacopoeia (the milk particles below 2um should not be less than 95%, and the milk particles above 5um should not be detected), add water for injection to 1000ml, cool, fill, and sterilize to get Zedoary oil injection emulsion. This process is a 1000ml prescription, and the production can be expanded, and nitrogen protection is required during the production process.

Embodiment 2

[0022] Add 6g of refined egg yolk lecithin into a solution containing 50g of xylitol, heat to 70°C, firstly use a tissue grinder at 8000-10000 rpm to stir for 3 times to disperse, then mix 10.0g of zedoary oil with refined Add 50g of soybean oil into the oil solution, stir 3 times under the same rotational speed to emulsify and disperse, and then emulsify through a high-speed homogenizer until it meets the requirements of the Pharmacopoeia (same example 1), add water for injection to a sufficient amount, cool the emulsion, and fill , and sterilized to obtain curcuma oil injection emulsion.

Embodiment 3

[0024] Dissolve 20.0g of turmeric oil, 15g of refined soybean lecithin in 100g of refined soybean oil, dissolve 22.5g of glycerin in water for injection, heat to 50°C respectively, mix well, disperse and emulsify in a tissue masher first, and then Emulsify with a homogenizer until the milk particles meet the requirements of the Pharmacopoeia (the milk particles below 2um should not be less than 95%, and the milk particles above 5um should not be detected), add water for injection to 1000ml, cool, fill, and sterilize to get Zedoary oil injection emulsion.

[0025] The zedoary oil injection emulsion prepared by the above-mentioned embodiments of the present invention has been studied in a stability test.

[0026] Curcuma Oil Injection

Curcuma Oil Glucose Injection

Curcuma Oil Injection Emulsion

Before sterilization

100

100

100

After sterilization

89

91

98

40°C Accelerated January

72 ...

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PUM

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Abstract

An emulsified injection of zedoary for treating viral disease, tumor and thrombus is proportionally prepared from the volatile zedoary oil, plant oil for injection, emulsifier and isotonic regulator through mixing.

Description

technical field [0001] The invention relates to a curcuma oil injection emulsion and a preparation method thereof. The medicine can be used for the treatment of diseases such as antiviral, antitumor and antithrombotic. technical background [0002] Curcuma is the rhizome of Curcuma aromatica Salisb (commonly known as warm Curcuma). Zedoary oil is the volatile oil contained in it, which can be distilled by traditional steam or as CO 2 Obtained by other methods such as supercritical extraction. Clinically, the volatile oil component can be used for anti-virus, anti-thrombosis and anti-tumor, etc., and can have satisfactory curative effect. At present, the injection-type pharmaceutical preparations using the volatile oil as an active pharmaceutical ingredient include zedoary oil injection and elemene emulsion. The injections include Zedoary Oil Injection, Zedoary Oil Glucose Injection (only suitable for children with viral pneumonia), all of which are transparent injections...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61P7/02A61P31/12A61P35/00
Inventor 肖春
Owner 肖春
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