Anti entity tumour medicinal composition

A technology of tumor drugs and compositions, which is applied in the field of drugs, and can solve the problems of limited and difficult local formation of effective drug concentrations in tumors, etc.

Inactive Publication Date: 2005-10-26
DASEN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the excessive expansion and hyperplasia of solid tumors, the interstitial pressure, tissue elastic pressure, fluid pressure and interstitial viscosity are all higher than those of the surrounding normal tissues. Therefore, it is difficult for conventional chemotherapy to form an effective drug concentration in the tumor. See Kong Qingzhong "Intratumoral placement of cisplatin plus systemic carmustine in the treatment of rat brain tumors" "Journal of Surgical Oncology" 69 pages 76-82 (1998) (Kong Q et al., J Surg Oncol.1998 Oct; 69( 2): 76-82), simply increasing the dosage is limited by systemic reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Put 80 mg of polyglycolic acid and glycolic acid copolymer (PLGA) with a molecular weight of 10,000 into a container, add 100 ml of dichloromethane, dissolve and mix well, add 10 mg of vincristine and 10 mg of mitomycin C, and re-shake After homogenization, the organic solvent was removed by vacuum drying. The dried solid composition is shaped immediately, subpackaged and then sterilized by radiation to obtain an anti-solid tumor pharmaceutical composition containing 10% vincristine and 10% mitomycin C, both by weight percentage. The drug release time of the anti-solid tumor pharmaceutical composition in physiological saline in vitro is 15-20 days, and the drug release time in mouse subcutaneous is 30-40 days.

Embodiment 2

[0089] The method step of being processed into the anti-solid tumor pharmaceutical composition is the same as in Example 1, but the difference is that the contained anti-cancer active ingredients are:

[0090] (A) 1-50% of vinblastine, isovinblastine, vinblastine, vinblastine, vinblastine, vincristine, podiazine, vincristine sulfate, vinblastine, anhydrovinblastine tartrate , Epoxy Vinblastine Tartrate, Epoxy Vinblastine, Vinblastine Tartrate, Hainan Crude Torresine, Hainan Crude Torrellactone, Vinpocetine, Vinorelbine, Bitartrate, Vinorelbine Ditartrate, Vinorel Tartrate Bin, vinblast, vinblast, vinblastol, vinblast, vinblastine sulfate, vinblast, vinblastine, vinblast, changflunine, vinbendine, vinblastine, vinblastine, Vinblastol, vinblastine, oxymatrine, harringtonine, deoxyharringtonine, homoharringtonine, pearl cyst shellin, monocrotaline, maytansin, erythrin, camel Total Alkaloids, Cardiolide, Maidensine, Rubescensine A, Zhangzhou Narcisine, Pronarcisine Hydrochloride,...

Embodiment 3

[0094]Put 80 mg of polyglycolic acid and glycolic acid copolymer (PLGA) with a molecular weight of 20,000 into a container, add 100 ml of dichloromethane, dissolve and mix well, add 10 mg of vinblastine and 10 mg of doxorubicin, and re-shake Dry in vacuo to remove the organic solvent. The dried solid composition is shaped immediately, subpackaged and sterilized by radiation to obtain an anti-solid tumor pharmaceutical composition containing 10% vinblastine and 10% doxorubicin. All are percentages by weight. The drug release time of the anti-solid tumor pharmaceutical composition in physiological saline in vitro is 15-20 days, and the drug release time in mouse subcutaneous is 30-40 days.

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PUM

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Abstract

A composite medicine for treating solid tumor by locally putting it in the tumor is composed of the active anticancer component (plant alkaloid and its symergist chosen from taxol-type anticancer medicine, antineoplastic antibiotic and antimetabolitic), and the medicinal auxiliary (biocompatible and biodegradable high-molecular polymer).

Description

(1) Technical field [0001] The invention relates to an anti-solid tumor pharmaceutical composition, which belongs to the technical field of medicines. (2) Background technology [0002] Cancer treatment mainly includes surgery, radiotherapy and chemotherapy. Among the various chemotherapeutic drugs used, plant alkaloids have obvious effects and have been widely used in various malignant tumors. However, after the single application of plant alkaloids, the DNA repair function in many tumor cells is significantly increased, so effectively reducing or inhibiting the DNA repair function in tumor cells has become the focus of current research. [0003] It has recently been found that inactivating or inhibiting intracellular DNA repair proteins can enhance the sensitivity of some tumor cells to chemotherapy, see Dolan et al. ""Cancer Research" 51 pp. 3367-3372 (1991) (Dolan et al., Cancer Res., 51, 3367-3372, 1991)). However, blood vessels, connective tissue, matrix proteins, f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/08
Inventor 孔庆忠孙娟于建江张红军
Owner DASEN BIOLOGICAL PHARMA CO LTD
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