Crystal for oral solid drug and oral solid drug for dysuria treatment containing the same

A technology for dysuria and solids, which can be used in drug combinations, pharmaceutical formulations, urinary system diseases, etc., and can solve the problems of unreported KMD-3213 crystalline polymorphic methods, unreported and mentioned which types of crystalline forms exist, preparation methods and its nature
CN1694867AInactive Publication Date: 2005-11-09KISSEI PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KISSEI PHARMA
Publication Date
2005-11-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

A crystal for oral solid drug comprised of indoline compound (KMD-3213) which exerts alpha1-adrenaline receptor shielding activity, is useful as a therapeutic agent for dysuria and is represented by the formula: (I) wherein in the powder X-ray diffraction pattern, the compound is characterized by main peaks of 5.5 DEG +- 0.2 DEG , 6.1 DEG +- 0.2 DEG , 9.8 DEG +- 0.2 DEG , 11.1 DEG +- 0.2 DEG , 12.2 DEG +- 0.2 DEG , 16.4 DEG +- 0.2 DEG , 19.7 DEG +- 0.2 DEG and 20.0 DEG +- 0.2 DEG as 2theta. There is further provided an oral solid drug for dysuria treatment containing the crystal as an active ingredient.
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Description

technical field

[0001] The invention relates to a crystal for oral solid medicine. More specifically, the present invention relates to crystals for oral solid medicine of indoline represented by the following general formula (hereinafter referred to as KMD-3213):

[0002]

[0003] it plays alpha 1 - Adrenergic receptors (α 1 -AR) blocking effect, and used as a therapeutic agent for dysuria; and relates to an oral solid medicament for treating dysuria comprising said crystal as an active ingredient.

[0004] The present invention also relates to an oral solid drug comprising KMD-3213 crystals for oral solid drug as active ingredients and α 1 - at least one of an AR blocker, an anticholinergic, a 5α-reductase inhibitor, a sex hormone, an anxiolytic, a cholinomimetic, a cholinesterase inhibitor, an anti-inflammatory, and an antibacterial.

[0005] Furthermore, the present invention relates to a medicine for treating dysuria, which comprises a medicine comprising KMD-3213 c...

Claims

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