Ring form effervescence dosage and preparation method thereof
An effervescent agent and annular technology, applied in the field of annular traditional Chinese medicine effervescent tablets and the preparation thereof, can solve the problems of affecting the disintegration speed, increasing the dosage of auxiliary materials, and not having outstanding advantages, so as to improve bioavailability and disintegration. Speed, the effect of reducing production costs
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Examples
Embodiment 1
[0028] The Kanggan granules contained on page 474 of the 2000 edition of the Chinese Pharmacopoeia were made into ordinary effervescent tablets and ring-shaped effervescent tablets.
[0029] Raw materials: 210 grams of honeysuckle, 210 grams of red peony root, 70 grams of Mianma Guanzhong.
[0030] Production Process:
[0031] Honeysuckle, Radix Paeoniae Rubra, and Mianmaguanzhong three flavors, add water and decoct twice, 1.5 hours each time, combine the decoction, filter, concentrate the filtrate to 250ml, add ethanol until the alcohol content reaches 50%, stir well, and let it stand overnight. Filtrate, recover ethanol from the filtrate, and concentrate to a clear paste with a relative density of 1.28-1.30 (50°C), dry it into extract powder to obtain 50 g, and store it in an airtight manner for future use. 100g of citric acid, 80g of sodium bicarbonate, and 30g of sodium carbonate were crushed through a 100-mesh sieve, and sealed for future use; 4g of stevia and 1g of esse...
Embodiment 2
[0041] "Chinese Pharmacopoeia)" 2000 edition one page 374 contained Xiaoermao granules were made into ordinary effervescent tablets and ring-shaped effervescent tablets.
[0042] Raw materials: 75 grams of patchouli, 75 grams of chrysanthemum, 75 grams of forsythia, 125 grams of Folium Isatidis, 75 grams of Radix Radix, 75 grams of Dihuang, 75 grams of Digupi, 75 grams of Baiwei, 50 grams of mint, and 125 grams of gypsum.
[0043] Production Process:
[0044] Dihuang, Baiwei, Digupi, and gypsum (100g) are decocted twice in water, the first time is 3 hours, and the second time is 1 hour. Combine the decoction and filter; chrysanthemum and Folium Once for 2 hours and for the second time for 1 hour, combine the extracts and filter; extract the volatile oils from patchouli, peppermint, and forsythia, filter their aqueous solutions, combine the filtrate with the above two liquids, and concentrate to a relative density of 1.30-1.35 (50 ℃), dried into extract powder to obtain 72g, s...
Embodiment 3
[0054] The Danxi Yupingfeng granules contained in the 20th volume of the "Ministerial Standards" are made into ordinary effervescent tablets and ring-shaped effervescent tablets.
[0055] Raw materials: 100 grams of Astragalus, 100 grams of Fangfeng, 200 grams of Atractylodes macrocephala (stir-fried bran).
[0056] Production Process:
[0057] The above three flavors are decocted twice with water, the first time is 2 hours, the second time is 1 hour, the decoction is combined, filtered, the filtrate is concentrated to a clear paste with a relative density of 1.30 (80-85°C), and dried into an extract powder. 37g was obtained, and sealed for future use; 70g of tartaric acid and 60g of potassium bicarbonate were pulverized through a 100-mesh sieve, and sealed for future use; 2g of cyclamate and 1g of essence were pulverized through a 100-mesh sieve, and 30g of magnesium stearate was pulverized through a 140-mesh sieve; During the process, the ambient temperature of the formulat...
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- Inventors
- 罗晓健; 吕爱平