Ring form effervescence dosage and preparation method thereof

An effervescent agent and annular technology, applied in the field of annular traditional Chinese medicine effervescent tablets and the preparation thereof, can solve the problems of affecting the disintegration speed, increasing the dosage of auxiliary materials, and not having outstanding advantages, so as to improve bioavailability and disintegration. Speed, the effect of reducing production costs

Active Publication Date: 2005-11-23
JIANGXI HERBFINE HI TECH
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  • Claims
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AI Technical Summary

Problems solved by technology

[0004] However, the effervescent dosage form of traditional Chinese medicine has a longer disintegration time than the other two types of effervescent dosage forms of health care products and effervescent dosage forms of western medicine, which affects the application of effervescent dosage forms of traditional Chinese medicine.
Most of the effervescent dosage forms of health care products contain substances that are easily soluble in water, such as small molecular substances and inorganic compounds that are easily soluble in water, and disintegrate quickly; Western medicines usually take a small amount and require less excipients to prepare effervescent dosage forms. Small effervescent formulations disintegrate quickly when exposed to water; effervescent dosage forms of health care products and Western medicine usually disintegrate within a minute or even within seconds, so there is no technical problem of poor practicability in terms of disintegration time
When traditional Chinese medicine is made into an effervescent dosage form, water extraction and alcohol extraction are usually used to obtain a variety of mixed macromolecular effective substances, including pectin, sugars, polysaccharides and other viscous substances. The disintegration is affected by viscous substances, and the disintegration is slow. On the other hand, in order to ensure the curative effect, the single-tablet Chinese medicine effervescent dosage form is taken in a large amount, which also affects the disintegration speed. In order to ensure disintegration, the excipients have to be increased The dosage makes some effervescent tablets need to be 4-5g / tablet, which not only increases the cost, but also brings inconvenience to production, transportation, carrying and use
The disintegration speed of traditional Chinese medicine effervescent agent is as long as several minutes, and the advantage is not prominent compared with traditional Chinese medicine granule, which also limits the application of traditional Chinese medicine effervescent agent

Method used

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  • Ring form effervescence dosage and preparation method thereof
  • Ring form effervescence dosage and preparation method thereof
  • Ring form effervescence dosage and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] The Kanggan granules contained on page 474 of the 2000 edition of the Chinese Pharmacopoeia were made into ordinary effervescent tablets and ring-shaped effervescent tablets.

[0029] Raw materials: 210 grams of honeysuckle, 210 grams of red peony root, 70 grams of Mianma Guanzhong.

[0030] Production Process:

[0031] Honeysuckle, Radix Paeoniae Rubra, and Mianmaguanzhong three flavors, add water and decoct twice, 1.5 hours each time, combine the decoction, filter, concentrate the filtrate to 250ml, add ethanol until the alcohol content reaches 50%, stir well, and let it stand overnight. Filtrate, recover ethanol from the filtrate, and concentrate to a clear paste with a relative density of 1.28-1.30 (50°C), dry it into extract powder to obtain 50 g, and store it in an airtight manner for future use. 100g of citric acid, 80g of sodium bicarbonate, and 30g of sodium carbonate were crushed through a 100-mesh sieve, and sealed for future use; 4g of stevia and 1g of esse...

Embodiment 2

[0041] "Chinese Pharmacopoeia)" 2000 edition one page 374 contained Xiaoermao granules were made into ordinary effervescent tablets and ring-shaped effervescent tablets.

[0042] Raw materials: 75 grams of patchouli, 75 grams of chrysanthemum, 75 grams of forsythia, 125 grams of Folium Isatidis, 75 grams of Radix Radix, 75 grams of Dihuang, 75 grams of Digupi, 75 grams of Baiwei, 50 grams of mint, and 125 grams of gypsum.

[0043] Production Process:

[0044] Dihuang, Baiwei, Digupi, and gypsum (100g) are decocted twice in water, the first time is 3 hours, and the second time is 1 hour. Combine the decoction and filter; chrysanthemum and Folium Once for 2 hours and for the second time for 1 hour, combine the extracts and filter; extract the volatile oils from patchouli, peppermint, and forsythia, filter their aqueous solutions, combine the filtrate with the above two liquids, and concentrate to a relative density of 1.30-1.35 (50 ℃), dried into extract powder to obtain 72g, s...

Embodiment 3

[0054] The Danxi Yupingfeng granules contained in the 20th volume of the "Ministerial Standards" are made into ordinary effervescent tablets and ring-shaped effervescent tablets.

[0055] Raw materials: 100 grams of Astragalus, 100 grams of Fangfeng, 200 grams of Atractylodes macrocephala (stir-fried bran).

[0056] Production Process:

[0057] The above three flavors are decocted twice with water, the first time is 2 hours, the second time is 1 hour, the decoction is combined, filtered, the filtrate is concentrated to a clear paste with a relative density of 1.30 (80-85°C), and dried into an extract powder. 37g was obtained, and sealed for future use; 70g of tartaric acid and 60g of potassium bicarbonate were pulverized through a 100-mesh sieve, and sealed for future use; 2g of cyclamate and 1g of essence were pulverized through a 100-mesh sieve, and 30g of magnesium stearate was pulverized through a 140-mesh sieve; During the process, the ambient temperature of the formulat...

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Abstract

The invention relates to a ring form effervescence dosage and preparation method, wherein a physical method is employed, by altering the external form of the tablets, the disintegrating speed of the Chinese medicinal effervescent tablets can be increased substantially, while not influencing the medicinal effect, the consumption of the disintegrating agent is reduced, and reducing the production costs, increasing the medicament release speed in human body. The invention also has the advantages of increased biological availability, and convenience in carrying and administration.

Description

technical field [0001] The invention relates to an annular effervescent dosage form and a preparation method thereof, in particular to an annular traditional Chinese medicine effervescent tablet and a preparation method thereof. Background technique [0002] Effervescent dosage forms often appear in the form of tablets. At present, the main effervescent tablets in my country are health care products, such as vitamin C effervescent tablets, and there are also effervescent tablets for gynecological external use, such as Jieeryin effervescent tablets, A Nitazole vaginal effervescent tablets, etc., but less oral Chinese medicine effervescence. In addition, ring-shaped tablets have been used in the food industry for a long time, but they are less used in the field of medicine, especially in the field of effervescent tablet preparation. There is no report on making traditional Chinese medicine into oral ring-shaped effervescent dosage forms. [0003] Traditional Chinese medicine e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 罗晓健吕爱平曾志斌饶小勇游剑
Owner JIANGXI HERBFINE HI TECH
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