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Method for realizing concentration measurement by employing flotation benchmarks

A concentration measurement and reference technology, which is applied in the field of substance concentration measurement using the floating reference method, can solve the problems of limiting the detection accuracy of trace components, unable to effectively eliminate the influence of interference signals, etc., so as to improve accuracy, eliminate noise, and improve measurement accuracy. Effect

Active Publication Date: 2005-11-23
TIANJIN SUNRISE TECH DEV
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Problems solved by technology

However, these three methods have their own different defects: a. Transmission method: Since the light source and detector are respectively arranged on both sides of the inspected part to receive the light passing through the human tissue, what it receives is the light path Through all the information on the path, however, due to the great differences in the measured individuals themselves, even compared to the same individual, the tissue differences at different times are also very serious, thus limiting the detection accuracy of transmission for trace components in the human body; b, Attenuated total reflection (ATR) method: The principle of total reflection is used to make the sample and the beam interact multiple times to improve the sensitivity of the output signal to the active components. However, the ATR method only measures the information on the surface of the medium, and in actual measurement, the surface layer There is a big difference between the blood glucose concentration and the actual blood glucose concentration; c. Diffuse reflection method: the light source and the detector are located on the same side of the tested part, and the signal of the received light comes from the backscattered light component of the tissue. The advantage is that the emission and reception All are on the same side of the measured medium, reducing the influence of individual differences and site differences
[0005] In summary, the prior art cannot effectively eliminate the influence of interference signals in the diffuse reflectance spectroscopy measurement, which is exactly the problem to be solved by the present invention

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  • Method for realizing concentration measurement by employing flotation benchmarks
  • Method for realizing concentration measurement by employing flotation benchmarks
  • Method for realizing concentration measurement by employing flotation benchmarks

Examples

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example 1

[0067] Example 1: Optical path selection method for measuring lactose content in milk

[0068] The main content of this program is to study the relationship between the absorption coefficient and scattering coefficient of milk with lactose concentration through experiments; then apply formula (5) to find the position of maximum sensitivity and minimum sensitivity Location.

[0069] The experimental device adopts a double integrating sphere system, and the light source is the FTIR spectrometer of PE Company, such as Figure 5 shown. Weigh 500, 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000 mg of lactose respectively, put them in a 50ml volumetric flask, and then add pure milk to the mark respectively. The diffuse reflectance Rd, diffuse transmittance Tt, and collimated transmittance Tc of each sample were measured in turn, and then Rd, Tt, and Tc were substituted into the inverse multiplication program to calculate the rate of change of the absorption coefficient and re...

example 2

[0074] Example 2: Optical path selection scheme for measuring glucose content in human skin

[0075] In this embodiment, the net analytical signal of glucose refers to the only useful signal in the measured human blood medium corresponding to the change of blood glucose, which is orthogonal to the space formed by all interference signals, and is the subtraction The pure analytical signal of the measured analyte after the interference vector. For non-invasive blood glucose measurement and detection, its data preprocessing needs to use net signal analysis and processing. The spectral signal is the result of the joint influence of various components in the blood and the physiological state of the skin surface. The noise space I in the net signal calculation is constructed by using the spectrum of the signal constant point C I C + , where I C is the spectral matrix measured at point C, I C + for the matrix I C pseudo-inverse of . This noise space has the same noise signal ...

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Abstract

The invention relates to a method for measuring concentration by floating reference, which comprises the following steps: using the testing object's concentration ratio aroused by light of testing media in different distance with light source to get measuring point and reference point; using the intensity value of measuring point and reference point to measure component concentration of the testing object which includes the following steps: measuring intensity parameter at reference point; measuring intensity parameter at measuring point; doing data preprocessing to measuring data; forming concentration and intensity weight differential mode single related mould; accomplishing concentration measurement of testing object.

Description

technical field [0001] The invention relates to a method for measuring substance concentration by near-infrared spectroscopy, in particular to a method for realizing substance concentration measurement by using a floating reference method. Background technique [0002] Currently, near-infrared spectroscopy is widely used to measure the concentration of substances. Among them, the non-invasive measurement of human blood glucose concentration by near-infrared spectroscopy is one of the frontier topics attracting worldwide attention. It can not only realize timely, safe and painless self-monitoring of blood glucose concentration, but also does not require consumables, which can greatly reduce the cost of testing. At the same time, the establishment of this theoretical method is not only applicable to blood glucose measurement, but also can be extended to other components in body fluids The non-invasive detection is of great significance to the develop...

Claims

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Application Information

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IPC IPC(8): G01N21/47
Inventor 徐可欣罗云瀚刘蓉
Owner TIANJIN SUNRISE TECH DEV
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